Search for dissertations about: "NATURAL SCIENCES Chemistry Organic chemistry Pharmaceutical chemistry"

Showing result 26 - 30 of 40 swedish dissertations containing the words NATURAL SCIENCES Chemistry Organic chemistry Pharmaceutical chemistry.

2. 26. Palladium(II)-Catalyzed Addition Reactions : Synthesis of Aryl Amidines and Aryl Ketones

   Author : Jonas Rydfjord; Mats Larhed; Adriaan Minnaard; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Palladium; Catalysis; Palladium II catalysis; Synthesis; Addition Reactions; Cyanamide; Amidine; Aryl Amidine; Nitrile; Ketone; Aryl Ketone; Carbopalladation; Continuous-flow; Continuous flow; Microwave heating; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Palladium-catalyzed reactions have become one of the most important tools in modern organic chemistry due to its ability to catalyze the formation of new carbon-carbon bonds.The aim of the work presented in this thesis was to develop new palladium(II)-catalyzed addition reactions. READ MORE

4. 27. Mercury species transformations in marine and biological systems studied by isotope dilution mass spectrometry and stable isotope tracers

   Author : Lars Lambertsson; Wolfgang Frech; John Munthe; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; Mercury; methylmercury; ethylmercury; Thimerosal; speciation; methylation; demethylation; brackish water sediment; natural waters; GC-ICP-MS; species-specific isotope dilution; isotope enriched tracers; Analytisk kemi; Analytical chemistry; Analytisk kemi; analytisk kemi; Analytical Chemistry;

   Abstract : This thesis focuses on the implementation of species-specific isotope dilution (SSID) methodology and stable isotope tracers to determine mercury species occurrence and transformation processes in-situ and during sample treatment. Isotope enriched tracers of methyl-, ethyl- and inorganic mercury were synthesised and applied in different combinations to marine and biological samples. READ MORE

5. 28. Synthesis of Indole Alkaloids and Development of New Methodology

   Author : Anita Hoang; Centrum för analys och syntes; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; total synthesis; indole alkaloids; Domino reactions; vicinal quaternary stereocenters; quaternary stereocenter; indoline synthesis; communesin alkaloid; perophoramidine; dehaloperophoramidine; akuammiline alkaloids; strictamine; intramolecular Heck reaction; domino carbopalladation carbonylation; indoline alkaloids;

   Abstract : This thesis describes our efforts towards the total synthesis of natural products and the development of a newmethodology to afford a synthetically important scaffold.Chapter 2 outlines our efforts towards the total synthesis of a marine natural product, perophoramidine as wellas our completed synthesis of dehaloperophoramidine. READ MORE

6. 29. Design, synthesis and evaluation of spiro-bicyclo[2.2.2]octane derivatives as paclitaxel mimetics

   Author : Sophie Manner; Centrum för analys och syntes; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; asymmetric baker s yeast reduction; paclitaxel; spiro; bicyclo[2.2.2]octane; paclitaxel mimetics;

   Abstract : Nature contains an endless supply of natural products and has for long been a source of inspiration for the pharmaceutical industry. Many of the drugs currently in clinical use originate from natural products. READ MORE

7. 30. Chemoenzymatic Dynamic Kinetic Resolution of Functionalized Secondary Alcohols

   Author : Richard Lihammar; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES;

   Abstract : Dynamic kinetic resolution (DKR) is the combination of a kinetic resolution with an in situ racemization and is a powerful method for obtaining optically active compounds. In this thesis various secondary alcohols are transformed to their corresponding enantiomerically enriched acetates by employing immobilized lipases as resolution catalysts and transition metal complexes as racemization catalysts. READ MORE