Search for dissertations about: "NATURAL SCIENCES Chemistry Organic chemistry Pharmaceutical chemistry"

Showing result 6 - 10 of 44 swedish dissertations containing the words NATURAL SCIENCES Chemistry Organic chemistry Pharmaceutical chemistry.

  1. 6. Synthesis of Spiro-bicyclo[2.2.2]Octane Derivatives Towards the Development of Paclitaxel Mimetics

    University dissertation from Organic Chemistry, Lund University

    Author : Viveca Thornqvist; Lunds universitet.; Lund University.; [2006]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Kemi; Organic chemistry; Organisk kemi; Chemistry; Natural science; paclitaxel; spiro; indium; Naturvetenskap; bicyclo[2.2.2]octane; allylation; paclitaxel mimetic;

    Abstract : Popular Abstract in Swedish Många av de föreningar som utvecklas i den farmaceutiska industrin idag har sina rötter i naturprodukter. Paclitaxel, den aktiva substansen i läkemedlet Taxol, återfinns bland annat i idegranens bark. READ MORE

  2. 7. Design, Synthesis and Thermodynamic Studies of Galectin Ligands

    University dissertation from Printed in Sweden by Media-Tryck, Lund University

    Author : Maria Luisa Verteramo; Lunds universitet.; Lund University.; [2019-05-10]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; galectin; conformational entropy; solvation; thermodynamic; interaction; molecular recognition; thiodigalactoside; diastereomer; structure-based design;

    Abstract : The word “medicine” has its origin from the Latin word medeor or medicor, which means to heal or to cure. Since ancient times, medicines helped to soothe the pain, which eventually resulted in general improvement of life. In a course of a lifetime, the use of medicines can vary according to the necessity. READ MORE

  3. 8. Biologically Interesting Compounds from Natural Sources

    University dissertation from Organic Chemistry, Lund University

    Author : Veronica de la Parra; Lunds universitet.; Lund University.; [2006]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; cytotoxicity; Natural products; terpenoids; vasorelaxant activity; allylmercaptane; diabetes mellitus type II; Organisk kemi; Organic chemistry; Cacalia decomposita; GPR40 receptor; TRP channel;

    Abstract : Natural products have traditionally played a major role in the drug discovery process. Besides constituting extremely popular drugs in the market, and an ever-increasing source of interesting and novel chemical structures, they have also aided the characterization of many a pharmacological target. READ MORE

  4. 9. Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors Targeting Different Genotypes and Drug-Resistant Variants

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anna Karin Belfrage; Uppsala universitet.; [2015]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; hepatitis C virus; HCV; NS3 protease inhibitors; structure-activity relationship; 2 1H -pyrazinone; quinazoline; resistance; Pd catalysis; Medicinal Chemistry; Läkemedelskemi; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Since the first approved hepatitis C virus (HCV) NS3 protease inhibitors in 2011, numerous direct acting antivirals (DAAs) have reached late stages of clinical trials. Today, several combination therapies, based on different DAAs, with or without the need of pegylated interferon-α injection, are available for chronic HCV infections. READ MORE

  5. 10. Exploring Palladium-Mediated 11C/12C-Carbonylation Reactions PET Tracer Development Targeting the Vesicular Acetylcholine Transporter

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sara Roslin; Uppsala universitet.; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Carbonylation; palladium; carbon-11; radiochemistry; positron emission tomography; vesicular acetylcholine transporter; vesamicol; alkyl halide; oxidative carbonylation; acylamidine; oxadiazole; heterocycle; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : The work presented herein describes the utilization and exploration of palladium-mediated incorporations of carbon monoxide and/or [11C]carbon monoxide into compounds and structural motifs with biological relevance.The first part of the thesis describes the design, synthesis and 11C-labeling of prospective PET tracers for the vesicular acetylcholine transporter (VAChT), a target affected in several neurodegenerative diseases. READ MORE