Search for dissertations about: "NFL"

Showing result 16 - 20 of 57 swedish dissertations containing the word NFL.

  2. 16. Brain parenchymal fraction in healthy individuals and in clinical follow-up of multiple sclerosis

    Author : Mattias Vågberg; Anders Svenningsson; Richard Birgander; Jonathan Gilthorpe; Anne-Marie Landtblom; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Brain parenchymal fraction; Neurofilament light; Glial fibrillary acidic protein; Brain atrophy; Multiple Sclerosis; Clinical follow-up;

    Abstract : Background Multiple sclerosis (MS) is an autoimmune disease characterised by inflammatory damage to the central nervous system (CNS). Accumulated CNS injury can be quantified as brain atrophy, definable as a reduction in brain parenchymal fraction (BPF). BPF correlate with disability in MS and is used routinely as an endpoint in clinical trials. READ MORE

  4. 17. Mapping the Huntington's disease process using cerebrospinal fluid analysis

    Author : Valter Niemelä; Anne-Marie Landtblom; Dag Nyholm; Jimmy Sundblom; Edward Wild; Uppsala universitet; []
    Keywords : Neurodegeneration; Huntingtons disease; Neurogenetics; Neuroinflammation; Neurofilament light; tau; Proenkephalin; Neurology; Neurologi;

    Abstract : Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, caused by a CAG-repeat expansion in the HTT-gene. Today there are no disease-modifying therapies (DMTs), but several promising clinical trials are underway, including therapies that reduce mutant huntingtin expression. READ MORE

  5. 18. Checkpoint inhibitor-induced adverse events in the CNS - T-cell characteristics and biomarkers

    Author : Sara Bjursten; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Immune checkpoint inhibition; Immune related adverse events to the CNS; T cells;

    Abstract : Immune checkpoint inhibitors (ICI) activate T cells to kill cancer cells by blocking inhibitory receptors PD-1 (nivolumab; nivo) or CTLA-4 (ipilimumab; ipi). Activated T cells can also attack any healthy organ, causing unpredictable immune related adverse events (irAE). The risk of irAE is highest when treating with ipi and nivo simultaneously. READ MORE

  6. 19. Markers and mechanisms of abnormal neurovascular development in the preterm infant

    Author : William Hellström; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neonatology; Brain development; Extremely preterm infant; Brain volume; Retinopathy of prematurity; Insulin-like growth factor 1; Neurofilament light; Neurodevelopment;

    Abstract : Background: The extremely preterm infant is at risk of lifelong neurodevelopmental impairments due to brain injuries or abnormal neurovascular development. Mechanisms are largely unknown and biomarkers for adverse outcomes are sparse. READ MORE

  7. 20. Treatment with the monoclonal antibody rituximab in Multiple Sclerosis : a study based on an academic clinical trial

    Author : Pierre de Flon; Anders Svenningsson; Martin Gunnarsson; Katarina Laurell; Sten Fredrikson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple sclerosis; Rituximab; Cytokines; Immunological profile; Neurofilament light; Treatment satisfaction; neurologi; Neurology;

    Abstract : Background: Multiple sclerosis (MS) is a chronic, inflammatory disease, affecting the central nervous system. A growing number of disease modifying treatment alternatives entails a need for an individualised risk-benefit- convenience analysis in the counselling of patients and methods to monitor the treatment effect, including markers for subclinical inflammation. READ MORE