Search for dissertations about: "NGS"
Showing result 6 - 10 of 73 swedish dissertations containing the word NGS.
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6. Mantle cell lymphoma strategies in primary treatment
Abstract : Mantle cell lymphoma (MCL) is associated with poor prognosis due to an aggressive clinical course. Being a rare disease, there are few randomized trials in MCL and there is no defined golden standard in primary treatment. READ MORE
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7. Advancing Evolutionary Biology: Genomics, Bayesian Statistics, and Machine Learning
Abstract : During the recent decades the field of evolutionary biology has entered the era of big data, which has transformed the field into an increasingly computational discipline. In this thesis I present novel computational method developments, including their application in empirical case studies. READ MORE
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8. Hunting a Silent Killer. Biomolecular Approaches in Ovarian Cancer
Abstract : Ovarian cancer is a heterogeneous disease and recent advances in improving patient outcome havebeen limited. It is estimated that a woman’s risk of developing ovarian cancer during her lifetime is about 1 in 70, making it a frequently occurring cancer type in women. READ MORE
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9. Using genetics to identify epigenetic and signal transduction targets in cancer
Abstract : Cancer arises mostly due to the stepwise acquisition of untamed growth capabilities by various means, ranging from genetic, epigenetic to environmental factors. With the advancement made in molecular biology and associated fields, the complex biological circuits leading to these pathological conditions have now started to be deciphered in-depth. READ MORE
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10. Genetic Studies of Immunological Diseases in Dogs and Humans
Abstract : This thesis presents genetic studies aiming at enlarging our knowledge regarding the genetic factors underlying two immune-mediated diseases, hypothyroidism and autoimmune Addison’s disease (AAD), in dogs and humans, respectively.Genetic and environmental factors are indicated to contribute to canine hypothyroidism, which can be considered a model for human Hashimoto’s thyroiditis (HT). READ MORE