Search for dissertations about: "NIS"

Showing result 1 - 5 of 31 swedish dissertations containing the word NIS.

  2. 1. SODIUM/IODIDE SYMPORTER-NIS Abundant and Important in Gastric Mucosa

    Author : Malin Josefsson; Neurogastroenterologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ussing chamber; MNNG; gastric iodide secretion; ouabain; gastric cancer; sodium perchlorate; gastric NIS; bile duct cancer; Sodium iodide symporter;

    Abstract : ABSTRACT Background: Iodine is essential for development and growth as a constituent in thyroid hormones. Biological mechanisms for iodide uptake and concentration are very important, espe-cially as iodine is a relatively scarce element. READ MORE

  4. 2. DNA damage affecting thyroidal iodide transport: an explanation to thyroid stunning

    Author : Madeleine Nordén; Göteborgs universitet; []
    Keywords : thyroid; radioiodide; thyroid stunning; NIS; cell cycle; genotoxic stress; DNA damage; H2AX; ATM;

    Abstract : 131I is widely used clinically in the treatment of Graves´ disease and differentiated thyroid cancer. However, cellular and molecular effects of 131I irradiation in relation to absorbed dose are poorly documented. READ MORE

  5. 3. Reversal of thyroid dedifferentiation and an invasive phenotype by small molecule kinase inhibitors: an experimental study on normal and malignant cells

    Author : Camilla Ingeson-Carlsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thyroid; cancer; NIS; MAPK; PI3K; BRAFV600E; migration; 3D culture;

    Abstract : Refractoriness to I-131 in dedifferentiated thyroid cancer is a great concern that restricts radioiodine therapy. There is also a lack of knowledge in understanding the mechanisms leading to repressed sodium iodide symporter (NIS) expression and impaired iodide uptake in tumor cells. READ MORE

  6. 4. The threat from non indigenous species - ecosystem vulnerability, global distribution and co-occurrence with other major threats

    Author : Helena Berglund; Biodiversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; threats; distribution range; isolation; endemism; invasions; invaders; vulnerability; non indigenous species; rarity; threatened species;

    Abstract : We live in a globalised world where people and goods travel large distances. Various species are brought along on these journeys, intentionally or as hitchhikers. Some of these species establish populations in regions to which they could not have spread without human assistance, and where they are considered to be non indigenous species (NIS). READ MORE

  7. 5. Gene expression of selected immune regulatory molecules in neuroimmunological diseases

    Author : Wen-Xin Huang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Multiple sclerosis (MS) is an inflammatory, demyelinating disease that is specific to the central nervous system (CNS). Myasthenia gravis (MG) is a disorder of the neuromuscular junction. Both MS and MG are usually considered autoimmune diseases but how the immune system is involved is poorly understood. READ MORE