Search for dissertations about: "NK-cells"

Showing result 31 - 35 of 258 swedish dissertations containing the word NK-cells.

  2. 31. Decoding NK cell receptor specificity : functional and structural studies of MHC class 1 subcomponents

    Author : Jakob Michaëlsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NK cells; MHC class 1; inhibitory receptors;

    Abstract : Natural Killer (NK) cells are an important part of the innate immune system. They can lyse target cells and secrete immunoregulatory cytokines early during immune responses. They mediate protection against viruses and tumours, and can reject MHC class I mismatched bone marrow grafts. READ MORE

  4. 32. Regulation of NK cell activity : studies of DAP12-associated receptors in immune synapse formation and in responses to cytomegalovirus infection

    Author : Hanna Sjölin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NK cells; DAP12; MCMV Cytokines; Receptors; Signaling; packages;

    Abstract : Natural killer (NK) cell effector functions are important for innate resistance against tumor cells and viral infections. NK cells display a broad range of inhibitory and activating receptors on the cell surface, which ensure specificity. READ MORE

  5. 33. NK cell inhibitory receptor interactions with MHC class I molecules

    Author : Jonas Sundbäck; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NK cells; MHC class I molecules; inhibitory receptors;

    Abstract : Natural killer (NK) cells represent the third population of lymphocytes in size after B- and T-cells. NK mediated killing of target cells is strongly influenced by MHC class I molecules expressed on target cells. In contrast to T-cells, NK cells can be inhibited by MHC class I molecules through the action of specific inhibitory NK cell receptors. READ MORE

  6. 34. NK cell and dendritic cell interactions in innate immune responses

    Author : Catrine M Persson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NK cells; Dendritic cells; crosstalk; recruitment; activation; CD94 NKG2AQa1; Toxoplasma gondii;

    Abstract : Natural killer (NK) cells are cytotoxic cells of the innate immune system. They have been found to be critical in the defense against infections and also against some tumors. Recent studies have shown that NK cells require signals from accessory cells to induce their recruitment and activation at the site of infection or tumor growth. READ MORE

  7. 35. Natural killer cell tolerance : influence of the MHC class I expression in the host

    Author : Maria H Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NK cells; MHC class 1; tolerance; transgenic mice; Ly49;

    Abstract : Development of self-tolerance in the immune system is characterized by somatic processes aiming at permanently eliminating, or silencing, potentially autoreactive lymphocytes. Such tolerance mechanisms are of outmost importance if autoimmunity is to be avoided. READ MORE