Search for dissertations about: "NKA"

Showing result 1 - 5 of 17 swedish dissertations containing the word NKA.

  2. 1. Studies on molecular mechanisms in calcium signaling and cellular energy consumption

    Author : Kalaiselvan Krishnan; Hjalmar Brismar; Anders Tengholm; KTH; []
    Keywords : ca2 signaling; ATP; PercevalHR; NKA; diabetes; Angiotensin; Biological Physics; Biologisk fysik;

    Abstract : Ion signaling plays fundamental role in cell survival. Na+ and Ca2+ are critical players in ion signaling. Cells spend the major amount of energy to maintain and regulate Na+ and Ca2+ gradients across the cell membrane. Any disruption in cellular energy consumption by plasma membrane ATPases affects ion signaling and vice versa. READ MORE

  4. 2. Functional significance of phosphorylation of rat renal Na+, K+-ATPase by PKA and PKC

    Author : Sam Xian Jun Cheng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Na ; K -ATPase; protein phosphorylation; cAMP-dependent protein kinase; protein kinase C; site-directed mutagenesis; DNA transfection; isoproterenol; [Ca2 ]i.;

    Abstract : The activity of Na+,K+-ATPase (NKA) is short term regulated by hormones as well as by signalling pathways that involve activation of PKA or PKC, but the mechanism(s) remains unclear. This study was performed to evaluate whether this regulation of NKA occurs via PKA- or PKC-mediated phosphorylation of the NKA a subunit. READ MORE

  5. 3. Na,K-ATPase as signaling transducer

    Author : Juan Li; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : It is now generally agreed that Na,K-ATPase (NKA), in addition to its role in the maintenance of Na+ and K+ gradients across the cell membrane, is a signal transducer. Our group has identified a novel signaling pathway where NKA interact with IP3R to form a signaling microdomain. READ MORE

  6. 4. The regulation of renal tubular Na+ transport is dependent on interaction between different hormones

    Author : Yoshiyuki Ohtomo; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Norepinephrine; oc-adrenergic; beta-adrenergic; neuropeptide Y; Na ; K -ATPase activity; C-peptide; ontogeny;

    Abstract : Renal Na+,K+-ATPase (NKA) is of great importance for the regulation of salt metabolism and its activity can be inhibited by several natriuretic hormones. So far, the effect of antinatriuretic factors have been less well studied. READ MORE

  7. 5. Organization of signaling networks during receptor-mediated membrane protein trafficking

    Author : Zongpei Chen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The mechanisms by which receptor signals are organized in a synergic/hierarchical manner in time and space during regulation of integral membrane protein traffic remain a present challenge. The aim of this study was to address some critical aspects of these processes. READ MORE