Search for dissertations about: "NMDA-receptors"

Showing result 6 - 10 of 53 swedish dissertations containing the word NMDA-receptors.

  2. 6. Development of in vitro and ex vivo positron-emitting tracer techniques and their application to neurotrauma

    Author : Sven Sihver; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Short-lived radionuclides; in vitro receptor binding; in vitro and ex vivo autoradiography; positron emission tomography; benzodiazepine; muscarinic acetylcholine; and NMDA receptors in CNS; experimental neurotrauma; Neurovetenskap; Neurology; Neurologi; medicinsk farmakologi; Medical Pharmacology;

    Abstract : The use of positron-emitting tracers has been extended beyond tomographic facilities in the last few years, giving rise to a general positron-emitting tracing technique. The methodological part of the present thesis involved the evaluation of the performance of storage phosphor (SP) plates, with tracers labeled with high-energy, short-lived, positron-emitting radionuclides, using homogenized tissue specimens and autoradiography with frozen brain sections. READ MORE

  4. 7. Importance of endogenous kynurenic acid in brainm catecholaminergic processes and in the pathophysiology of schizophrenia

    Author : Sophie Erhardt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Schizophrenia; kynurenic acid; nicotine; VTA; dopamine; NMDA-receptors;

    Abstract : Kynurenic acid is a metabolite of tryptophan and the only known naturally occurring NMethylD-Aspartic acid (NMDA)-receptor antagonist (at the co-agonist glycine site) in the human brain. The aim of the present work was to investigate the physiological and pharmacological significance of endogenous kynurenic acid as well as its putative pathophysiological implications. READ MORE

  5. 8. Interactions between neuronal nicotinic acetylcholine receptors, N-methyl-aspartate receptors and beta-amyloid in the brain of genetically modified mice : implications for Alheimer's disease

    Author : Christina Unger; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Abeta; Alzheimer s disease; APP; nAChR; NMDA receptors; synaptophysin; transgenic mice; treatment;

    Abstract : The amyloid hypothesis is one of the leading theories in the search for the cause of Alzheimer's disease (AD) and is based on the theory that hyperproduction and accumulation of amyloid betapeptide (Abeta) in the brain triggers the disruption of neuronal and synaptic function, thereby ultimately leading to neurodegeneration and dementia. Some of the crucial questions are if Abeta has a neuronal function in the brain and how it interacts with the neurotransmitter system in AD. READ MORE

  6. 9. Afferent input to midbrain dopamine neurones and its modulation : an electrophysiological study i vitro

    Author : Pernilla Grillner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : dopamine neurones; synaptic transmission; NMDA receptors; L-type Ca2 channels; presynaptic inhibition; metabotropic glutamate receptors; muscarine; nicotine;

    Abstract : Dopamine (DA) neurones of the ventral mesencephalon are involved in the control of reward related behaviour, cognitive functions and motor performances, and provide a critical site of action for major categories of neuropsychiatric drugs, such as antipsychotic agents, dependence producing drugs and anti-Parkinson medication. The midbrain DA neurones are mainly located in the substantia nigra pars compacta (SNPC) and the ventral tegmental area (VTA). READ MORE

  7. 10. Regulation of NMDA receptor properties by amino acids and cations : a biochemical and electrophysiological study

    Author : Yun Liu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NMDA receptor; Glutamate; Glycine; [3H]MK-801 binding; Magnesium; Calcium; Tris; Potassium; Sodium; Proton; Xenopus oocytes; Spinal cord; Cerebral cortex; Receptor binding; Electrophysiology;

    Abstract : NMDA receptors are glutamate-regulated ion channels that are permeable to Ca2+, Na+ and K+ and are sensitive to voltage-dependent Mg2+-block. To investigate the modulatory effects of amino acids and cations on NMDA receptors and the possible regional differences in the pharmacology of NMDA receptors, I used mainly two techniques in this thesis: electrophysiological analysis of expressed NMDA receptors in Xenopusoocytes and biochemical receptor binding using [3H]MK-801 in membrane preparations from the rat cerebral cortex and spinal cord. READ MORE