Search for dissertations about: "NMDA"
Showing result 21 - 25 of 155 swedish dissertations containing the word NMDA.
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21. Labelling of nucleoside analogues and NMDA receptor antagonists with 11C
Abstract : .... READ MORE
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22. Herpesvirus Infection and Immunity in Neurocognitive Disorders
Abstract : Herpesviruses have co-speciated with several vertebrate and invertebrate animals throughout the history of evolution. In the immunocompetent human host, primary infection is usually benign, whereafter the virus is brought into life-long latency. READ MORE
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23. Effects of ethanol on NMDA receptor-mediated functions in primary cultures of cerebellar granule cells
Abstract : Primary cultures of cerebellar granule cells were used to investigate the effects of acute and chronic exposure of ethanol on NMDA receptor functions and to examine the possible sites of interaction between ethanol and the NMDA receptor. Activation of NMDA receptors induced elevation of free cytoplasmic Ca2+, Ca2+ influx, activation of protein kinase C and neurotoxicity. READ MORE
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24. Physiopathological aspects of NMDA transmission in the basal ganglia : in vitro and in vivo release studies
Abstract : N-methyl-D-aspartic acid (NMDA) is an excitatory amino acid selectively acting on a subclass of glutamate receptors (the NMDA ionotropic receptor) which has been involved in many of the physiological and pathological effects of glutamate in the CNS. The basal ganglia are particularly enriched in NMDA receptors and NMDA receptor activation in the basal ganglia has been involved in the expression of motor behaviour. READ MORE
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25. Synthesis and structure activity relationships of competitive NMDA antagonists with analgesic activity
Abstract : The compounds cis-3-(1-oxo-2-phosphonoethyl)-2-piperidinecarboxylic acid 1 and cis-3-(1-hydroxy-2-phosphonoethyl)-2-piperidinecarboxylic acid 2 were synthesized and found to be potent N-methyl-D-aspartate (NMDA) antagonists. NMR analysis showed that 1 prefers a 2eq,3ax chair conformation probably due to a conformer-stabilizing internal hydrogen bond. READ MORE