Search for dissertations about: "NMR peptide structure"

Showing result 1 - 5 of 55 swedish dissertations containing the words NMR peptide structure.

  2. 1. NMR studies of the amyloid beta-peptide

    Author : Jens Danielsson; Astrid Gräslund; Chris Dobson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NMR; amyloid beta peptide; structure; metal interaction; diffusion; Biophysics; Biofysik;

    Abstract : The Amyloid beta peptide (Ab) is related to Alzheimer’s disease and is suggested to be the molecular pathogenic species of the disease, probably through the neurotoxic effect of Ab oligomers. Here the results from biophysical studies of Ab and fragments thereof, are presented. READ MORE

  4. 2. Studies of protein structure, dynamics and protein-ligand interactions using NMR spectroscopy

    Author : Tobias Tengel; Göran Larsson; Maria Sunnerhagen; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; 19F NMR; 2S albumin; PapD; protein-ligand interaction; structure; TFE; Yersinia; YopD; allergy; amphipathic helix; Ber e 1; Brazil nut; dynamics; FimC; LcrH; NMR screening; Biophysics; Biofysik;

    Abstract : In the first part of the thesis, protein-ligand interactions were investigated using the chaperone LcrH, from Yersinia as target protein. The structure of a peptide encompassing the amphipathic domain (residue 278-300) of the protein YopD from Yersinia was determined by NMR in 40% TFE. READ MORE

  5. 3. NMR as a tool in drug research : Structure elucidation of peptidomimetics and pilicide-chaperone complexes

    Author : Mattias Hedenström; Jan Jan Kihlberg; Ingmar Sethson; Michael P. Williamson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; NMR; structure calculations; peptidomimetics; desmopressin; Leu-enkephalin; chemical shift mapping; pilicides; chaperones; urinary tract infections.; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Abstract : In the last decades NMR spectroscopy has become an invaluable tool both in academic research and in the pharmaceutical industry. This thesis describes applications of NMR spectroscopy in biomedicinal research for structure elucidation of biologically active peptides and peptidomimetics as well as in studies of ligand-protein interactions. READ MORE

  6. 4. Synthesis, conformational analysis, and biological evaluation of peptides from E. coli P pilus proteins

    Author : Katarina Flemmer Karlsson; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NMR spectroscopy; CD spectroscopy; peptide structure; ELISA; solid-phase peptide synthesis; peptide; P pili; chaperone; Organic chemistry; Organisk kemi;

    Abstract : Many bacteria utilize hairlike protein appendages (pili) to attach themselves to mucosal cell surfaces in the host organism. The pilus is assembled from protein subunits synthesized inside the bacteria and transported to the outer cell wall for incorporation into the growing pilus. READ MORE

  7. 5. Structure and function of relaxins

    Author : Linda M. Haugaard-Kedström; Johan Rosengren; Torleif Härd; Linnéuniversitetet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; relaxin; insulin-like peptide; peptide hormone; peptide synthesis and NMR; Organic Chemistry; Organisk kemi;

    Abstract : The relaxin/insulin superfamily is a group of peptide hormones that consists of ten members in human, namely relaxins 1-3, insulin-like peptides (INSL) 3-6, insulin and insulin-like growth factors (IGF) I-II. These peptides have various functions in the body, such as regulating growth, blood glucose levels,  collagen metabolism, germ cell maturation and appetite. READ MORE