Search for dissertations about: "NNRTls"

Found 2 swedish dissertations containing the word NNRTls.

2. 1. Reverse transcriptase assay for analysis of resistance to anti-HIV drugs and their mechanism of action

   Author : Xingwu Shao; Karolinska Institutet; Karolinska Institutet; []
   Keywords : HIV-1; RT; antiviral drugs; NRTls; NNRTls; drug resistance; viral load;

   Abstract : Reverse transcriptase (RT) is a viral enzyme and one of the main targets for drugs against human immunodeficiency virus (HIV). This work presents a set of sensitive non-radioactive RT assays were developed: standard RT inhibition assay (IC assay); RT binding inhibition assay; RTprotein detection assay and template-primer destruction assay or chain termination assay (CT assay). READ MORE

4. 2. HIV-1 reverse transcriptase as a target in the development of specific enzyme inhibitors

   Author : Hong Zhang; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Human immunodeficiency virus type I (HIV-I), which causes the acquired immunodeficiency syndrome (AIDS), begins its intracellular infection life cycle with reverse transcription of its plus-strand RNA genome into a double-stranded proviral DNA intermediate which is integrated into the host chromosome inducing a persistent infection. A virally encoded enzyme, reverse transcriptase (RT), carries out the reverse transcription process by performing all three enzymatic activities, i. READ MORE