Search for dissertations about: "NOD mice"

Showing result 1 - 5 of 59 swedish dissertations containing the words NOD mice.

  2. 1. The genetic basis of T and B cell contribution to autoimmune diabetes in NOD mice

    Author : Vinícius Motta; Dan Holmberg; Linda Wicker; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 Diabetes; NOD mouse; CTLA-4; superantigen; T cells; Idd; marginal zone B cells; embryo aggregation chimera; negative selection; Immunogenetics; Immungenetik;

    Abstract : The nonobese diabetic mouse (NOD) is an excellent animal model to study type 1 diabetes. As with some humans, disease in the NOD mouse is effected by a combination of genetic and environmental factors. At least 20 insulin dependent diabetes (Idd) susceptibility loci have been identified so far, both in humans and in the NOD mouse. READ MORE

  4. 2. Anomalies in humoral immunity in the NOD mouse : contribution to the progression of type 1 diabetes

    Author : Radha Thyagarajan; Kristina Lejon; Per-Arne Oldenborg; Susanna Cardell; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 Diabetes; NOD mouse; B cells; IgE; TACI; BAFF; immunologi; Immunology;

    Abstract : The non-obese diabetic (NOD) mouse is widely used model Type 1 diabetes (T1D), a chronic inflammatory disease characterized by destruction of the insulin producing β cells in the islets of Langerhans by immune cells. The classical symptoms include increased glucose levels in urine and blood, frequent urination and enhanced thirst. READ MORE

  5. 3. MHCI-E mediated protection from IDDM on NOD mice : The role of regulatory T cells

    Author : Nina Brenden; Ronald Jonsson; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; immunologi; Immunology;

    Abstract : .... READ MORE

  6. 4. Islet insulin secretory patterns in diabetes and the role of UCP2

    Author : Jian-Man Lin; Valdemar Grill; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; type 1 diabetes; type 2 diabetes; NOD; GK; congenes; KKAy; human; islet; glucose; insulin release; oscillation; frequency; amplitude; oxidation; respiration; UCP2; western blot; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : During development of type 1 and type 2 diabetes plasma insulin patterns are altered. Since the islet insulin release pattern has been implicated in this development, insulin secretion from single islets was studied and linked to the islet protein levels of uncoupling protein-2 (UCP2). READ MORE

  7. 5. Cytokine regulation of pancreatic -cell function with special reference to the pathogenesis of type 1 diabetes

    Author : Johnny Sternesjö; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pancreatic islets; insulin secretion; cytokines; nitric oxide; streptozotocin; NOD mice; proteasome; nuclear factor-kappaB; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Cytokines produced by inflammatory cells have been implicated in the pathogenesis of type 1 diabetes. The overall aim of the present work was to test how different cytokines, supposed to be present in the insulitic lesion, could influence the function of islets of Langerhans. READ MORE