Search for dissertations about: "NOD mice"
Showing result 6 - 10 of 59 swedish dissertations containing the words NOD mice.
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6. Aspects of T cell development contributing to autoimmunity
Abstract : Autoimmunity, such as type 1 diabetes (T1D), arises as a result of tolerance breakdown against host tissues, i.e. the β-cells. Central tolerance is established during thymic T cell development and defects in key events during this process could contribute to the pathogenesis of autoimmune diseases. READ MORE
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7. Prevention of type 1 diabetes mellitus in experimental studies
Abstract : The aim of the study was to examine the immune response and different immunoprotective strategies in experimental type 1 diabetes mellitus. The autoimmune destruction of the insulin-producing pancreatic β-cells that leads to type 1 diabetes is complex and incompletely understood. READ MORE
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8. Investigations of Strategies to Counteract Proinflammatory Cytokines in Experimental Type 1 Diabetes
Abstract : Type 1 diabetes (T1D) is a chronic autoimmune disease targeted against the pancreatic β-cells. Proinflammatory cytokines are considered to play a major role in the destruction of the insulin-producing β-cells. This thesis studied strategies to counteract proinflammatory cytokines in experimental T1D. READ MORE
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9. Aspects of the glomerular barrier in healthy and diabetic kidneys
Abstract : Each day 180 liters of plasma is filtered in the kidneys. Under normal conditions, the glomerular barrier restricts the passage of macromolecules such as albumin while it is highly permeable to water and small solutes. Proteinuria is a hallmark of renal disease and reflects impairment of the glomerular barrier. READ MORE
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10. B cell deviations and type 1 diabetes in the NOD mouse
Abstract : Type 1 diabetes (T1D) is a chronic autoimmune disease in which the insulin producing β-cells in the pancreatic islets of Langerhans are selectively attacked by the immune system. The β-cells are destroyed resulting in a reduced or eliminated insulin production, which in turn lead to a high blood glucose level. READ MORE