Search for dissertations about: "NOD"
Showing result 1 - 5 of 102 swedish dissertations containing the word NOD.
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1. Anomalies in humoral immunity in the NOD mouse : contribution to the progression of type 1 diabetes
Abstract : The non-obese diabetic (NOD) mouse is widely used model Type 1 diabetes (T1D), a chronic inflammatory disease characterized by destruction of the insulin producing β cells in the islets of Langerhans by immune cells. The classical symptoms include increased glucose levels in urine and blood, frequent urination and enhanced thirst. READ MORE
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2. Islet insulin secretory patterns in diabetes and the role of UCP2
Abstract : During development of type 1 and type 2 diabetes plasma insulin patterns are altered. Since the islet insulin release pattern has been implicated in this development, insulin secretion from single islets was studied and linked to the islet protein levels of uncoupling protein-2 (UCP2). READ MORE
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3. Aspects of T cell development contributing to autoimmunity
Abstract : Autoimmunity, such as type 1 diabetes (T1D), arises as a result of tolerance breakdown against host tissues, i.e. the β-cells. Central tolerance is established during thymic T cell development and defects in key events during this process could contribute to the pathogenesis of autoimmune diseases. READ MORE
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4. B cells in Type 1 diabetes : studies on cell surface antibody binding
Abstract : .... READ MORE
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5. B cell deviations and type 1 diabetes in the NOD mouse
Abstract : Type 1 diabetes (T1D) is a chronic autoimmune disease in which the insulin producing β-cells in the pancreatic islets of Langerhans are selectively attacked by the immune system. The β-cells are destroyed resulting in a reduced or eliminated insulin production, which in turn lead to a high blood glucose level. READ MORE