Search for dissertations about: "NOE SPECTROSCOPY"
Showing result 1 - 5 of 10 swedish dissertations containing the words NOE SPECTROSCOPY.
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1. Structure, dynamics and interactions of biomolecules : Investigations by NMR spectroscopy and computational methods
Abstract : In this thesis, the structure, dynamics and interactions of proteins and carbohydrates are investigated using mainly NMR spectroscopy and computer simulations. Oligosaccharides representing a Salmonella O-antigen have been synthesized and their dynamic behavior and interaction with the bacteriophage P22 tail-spike protein have been studied by NMR spectroscopy, MD and docking simulations. READ MORE
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2. Conformational Studies of Biologically Active Peptides
Abstract : In this work conformational studies have been performed on peptides from four different systems in an attempt to gain knowledge about their biological function. Circular dichroism (CD) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy in combination with distance geometry and restrained molecular dynamics simulations were the methods used. READ MORE
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3. Structural and conformational studies of bacterial polysaccharides employing NMR spectroscopy
Abstract : Methods and approaches for performing structural and conformational analysis of bacterial polysaccharides in solution are described. The structure of one exopolysaccharide from Lactobacillus helveticus and two O-antigens from Escherichia coli have been determined using NMR spectroscopy, chemical degradation and mass spectrometry. READ MORE
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4. Structural Studies of O-antigen polysaccharides, Synthesis of 13C-labelled Oligosaccharides and Conformational Analysis thereof, using NMR Spectroscopy
Abstract : In order to understand biological processes, to treat and diagnose diseases, find appropriate vaccines and to prevent the outbreak of epidemics, it is essential to obtain more knowledge about carbohydrate structures. This thesis deals with structure and conformation of carbohydrates, analysed by NMR spectroscopy and MD simulations. READ MORE
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5. Studies of protein structure, dynamics and protein-ligand interactions using NMR spectroscopy
Abstract : In the first part of the thesis, protein-ligand interactions were investigated using the chaperone LcrH, from Yersinia as target protein. The structure of a peptide encompassing the amphipathic domain (residue 278-300) of the protein YopD from Yersinia was determined by NMR in 40% TFE. READ MORE