Search for dissertations about: "NONMEM markov"
Found 4 swedish dissertations containing the words NONMEM markov.
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1. Methodological Studies on Models and Methods for Mixed-Effects Categorical Data Analysis
Abstract : Effects of drugs are in clinical trials often measured on categorical scales. These measurements are increasingly being analyzed using mixed-effects logistic regression. However, the experience with such analyzes is limited and only a few models are used. READ MORE
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2. Models for Ordered Categorical Pharmacodynamic Data
Abstract : In drug development clinical trials are designed to investigate whether a new treatment is safe and has the desired effect on the disease in the target patient population. Categorical endpoints, for example different ranking scales or grading of adverse events, are commonly used to measure effects in the trials. READ MORE
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3. Pharmacometric models in the development of biological medicinal products
Abstract : Biological medicinal products (BMPs) are a successful class of drugs that are indicated in numerous diseases. Common among them is that complexities associated with their manufacture and analysis lead to a high cost compared to small-molecular weight drugs. READ MORE
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4. Pharmacometrics to improve clinical benefit assessment in oncology
Abstract : The high attrition rate in oncology drug development calls for new approaches that would increase the understanding of drugs’ efficacy and safety profiles. This thesis focuses on the development of pharmacometric models to characterize and quantify the relationships between drug exposure, circulating and imaging biomarkers, adverse effects, overall survival (OS), and patient-reported outcomes (PROs). READ MORE