Search for dissertations about: "NPC1L1"

Found 4 swedish dissertations containing the word NPC1L1.

  1. 1. Regulation of the hepatic ACAT2 expression and roles of HNF1alhpa and HNF4alpha in cholesterol metabolism

    Author : Camilla Pramfalk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; ACAT2; HNF; MODY; NPC1L1; SREBP; cholesterol metabolism;

    Abstract : Acyl-Coenzyme A:cholesterol acyltransferases (ACATs) 1 and 2 are integral membrane proteins located in rough endoplasmatic reticulum that catalyzes the formation of cholesteryl esters (CEs) from cholesterol and long-chain fatty acids. ACAT1 is present in most tissues, whereas ACAT2 is confined to enterocytes and hepatocytes. READ MORE

  2. 2. Studies on cholesterol and bile acid metabolism in Chinese cholesterol gallstone patients

    Author : Zhao-Yan Jiang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Cholesterol gallstone disease; ABCG5 ABCG5; SRBI; ACAT2; Gender; Bile acids; Liver; Intestine;

    Abstract : Liver and intestine are important organs for the metabolism of cholesterol and bile acids in the body. Dysfunction in cholesterol and bile acid metabolism may lead to diseases such as cholesterol gallstone (GS) disease and atherosclerosis. READ MORE

  3. 3. Studies on the effects of thyroid hormone on cholesterol and lipoprotein metabolism

    Author : Ylva Bonde; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Elevated plasma lipids, particularly cholesterol within low density lipoproteins, is an important risk factor for developing atherosclerosis which can cause angina pectoris, myocardial infarction, and stroke. Thyroid hormone (TH) has a strong influence on lipid metabolism and the aim of this thesis was to gain more insight into how TH modulates cholesterol and lipoprotein metabolism. READ MORE

  4. 4. Functional study of nuclear receptors and bile acids in the modulation of cholesterol homeostasis

    Author : Xiaoli Hu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Cholesterol carries multiple biological functions in the body, and imbalanced cholesterol metabolism lead s to atherosclerosis and cardiovascular diseases. The present thesis aims to extend the knowled ge of cholesterol metabolic regulation mediated by nuclear receptor LXRs and bile acids, two major players in the homeostasis of body cholesterol. READ MORE