Search for dissertations about: "NRAS"

Showing result 1 - 5 of 17 swedish dissertations containing the word NRAS.

  2. 1. Molecular Signatures of Cancer

    Author : Esther Edlundh-Rose; Joakim Lundeberg; Peter Södervist; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; : BRAF; NRAS; MGMT; methylation; pyrosequencing; microarray technology; gene expression analysis; Molecular biology; Molekylärbiologi;

    Abstract : Cancer is an important public health concern in the western world, responsible for around 25% of all deaths. Although improvements have been made in the diagnosis of cancer, treatment of disseminated disease is inefficient, highlighting the need for new and improved methods of diagnosis and therapy. READ MORE

  4. 2. Molecular Genetic Studies on Prostate and Penile Cancer

    Author : Patiyan Andersson; Peter Söderkvist; Mattias Höglund; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; IRS1; penile cancer; hTERT; FHIT; PIK3CA; HRAS; KRAS; NRAS; BRAF; Oncology; Onkologi;

    Abstract : This thesis is comprised of two parts. In the first part we study the influence of four frequently disputed genes on the susceptibility for developing prostate cancer, and in the second part we attempt to establish a basic understanding of the molecular genetic events in penile cancer. READ MORE

  5. 3. Molecular genetics of cutaneous malignant melanoma

    Author : Malihe Eskandarpour; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cutaneous malignant melanoma is an aggressive tumor of melanocytes in the skin with rapidly increasing incidence. Patients with advanced disease have a poor prognosis since the tumor is usually resistant to current therapies. Therefore, the development of novel strategies for preventing and treating melanoma is important. READ MORE

  6. 4. Activating proto-oncogene mutations in human cutaneous melanoma

    Author : Katarina Omholt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cutaneous melanoma arises from melanocytes located in the basal layer of the epidermis. The disease is known to progress through well-defined steps: 1) common nevus; 2) dysplastic nevus; 3) radial growth phase (RGP) primary melanoma; 4) vertical growth phase (VGP) primary melanoma; and 5) metastatic melanoma. READ MORE

  7. 5. Molecular studies in different types of melanoma tumors : correlations to clinical data

    Author : Abdlsattar Zebary; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Approximately 90% of melanomas arise from skin sites (known as cutaneous malignant melanoma; CMM), whereas the non-cutaneous melanoma (mucosal and ocular melanomas) are rare, accounting for about 10%. Familial melanoma accounts for up to 10% of patients diagnosed with CMM. Both genetics (e.g. READ MORE