Search for dissertations about: "NRTIs"

Found 4 swedish dissertations containing the word NRTIs.

  2. 1. Studies of Retroviral Reverse Transcriptase and Flaviviral Protease Enzymes as Antiviral Drug Targets : Applications in Antiviral Drug Discovery & Therapy

    Author : Muhammad Junaid; Jarl ES Wikberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virus; enzymes; HIV AIDS; retroviral reverse transcriptase; flaviviral protease; NRTIs; proteochemometrics; drug resistance; DEN; JEV; NS2B H -NS3pro; antiviral; drug targets; drug discovery; drug therapy.; Farmakologi; Pharmacology;

    Abstract : Viruses are a major threat to humans due to their unique adaptability, evolvability and  capability to control their hosts as parasites and genetic elements. HIV/AIDS is the third largest cause of death by infectious diseases in the world, and drug resistance due to the viral mutations is still the leading cause of treatment failure. READ MORE

  4. 2. The HIV-1 epidemic in Ethiopia – transmission patterns, antiretroviral drug resistance and treatment outcomes

    Author : Dawit Assefa; Malmö Klinisk virologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; HIV drug resistance HIVDR ; Phylodynamics; Phylogenetic; Molecular epidemology; transmitted HIVDR; acquired HIVDR; pre-treatment HIVDR; Integrase strand transfer inhibitors INSTI ; Ethiopia; antiretroviral therapy;

    Abstract : A comprehensive understanding of local HIV epidemiology is essential for monitoring transmission, designing, implementing, and evaluating HIV intervention strategies. In paper I, we used a total of 1276 HIV-1 subtype C pol sequences and employed state-of-art phylogenetic and phylodynamic tools to describe the molecular epidemiology of HIV in Ethiopia. READ MORE

  5. 3. Optimization of pediatrics antiretroviral treatment outcomes among HIV infected children in Ethiopia

    Author : Birkneh Tilahun Tadesse; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Ending the HIV/AIDS epidemic by 2030 is a global agenda. To meet this global goal, having safe and effective antiretroviral therapy is a key requirement. In Ethiopia, the safety and efficacy of combination antiretroviral therapy in HIV infected pediatric population is poorly studied. READ MORE

  6. 4. Antiretroviral drug resistance and treatment outcomes of human immunodeficiency virus type-1 : implications for low and middle income countries

    Author : Amanda Häggblom; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : My thesis contains comprehensive studies of antiretroviral treatment (ART) naïve and experienced patients from the beginning of the Swedish HIV-1 epidemic. Paper I was the first study to describe the ART usage and occurrence acquired drug resistance mutations (DRM) at a population level in Sweden over time and we used data derived between 1997-2011. READ MORE