Search for dissertations about: "NS3"

Showing result 21 - 25 of 45 swedish dissertations containing the word NS3.

  2. 21. Design and Synthesis of Inhibitors Targeting the Hepatitis C Virus NS3 Serine Protease and the Aspartic Protease BACE-1

    Author : Marcus Bäck; Ingemar Kvarnström; Stephen Hanessian; Linköpings universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : This thesis describes the synthesis of molecules designed to inhibit the hepatitis C virus (HCV) NS3 serine protease and the human aspartic protease BACE-1, and it also reports the structure-activity relationships between potential inhibitors and the targeted enzymes. In addition, consideration is given to the class of enzymes known as proteases, as well as the question of why such enzymes can be regarded as suitable targets for developing drugs to combat diseases in general. READ MORE

  4. 22. Development of a therapeutic vaccine against the hepatitis C virus

    Author : Gustaf Ahlén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HCV; NS3; DNA vaccine; electroporation;

    Abstract : The hepatitis C virus (HCV) infection is a major cause of liver disease and it is estimated that 170 million people worldwide are chronically infected by HCV. There are no protective or curable vaccines available for HCV, however treatment consisting of interferon-α and ribavirin is curative in 45-75% of the chronic infected patients, depending on the viral genotype. READ MORE

  5. 23. Design and synthesis of inhibitors that target the serine protease thrombin, the malarial aspartyl proteases plasmepsin I and II, and the hepatitis C virus NS3 serine protease

    Author : Per-Ola Johansson; Mats Larhed; Linköpings universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : This thesis addresses the design, synthesis, and structure-activity relationships of protease inhibitors that target the serine protease thrombin, the malarial aspartic proteases plasmepsin I and II, and the hepatitis C virus (HCV) NS3 serine protease. Furthermore, the backgrounds of each of the three types of diseases in question are discussed in detail, and consideration is given as to why it is assumed that inhibition of the mentioned proteases will help prevent or cure cardiovascular diseases, malaria, and hepatitis C. READ MORE

  6. 24. The hepatitis C virus and immune escape : relation between sequence variations and the in vitro and in vivo functionality of the non-structural 3/4A complex

    Author : Jonas Söderholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HCV; NS3; HLA-A2; viral fitness; DNA vaccine;

    Abstract : The hepatitis C virus (HCV) is a blood-borne virus responsible for a major part of liver transplants is the US, and 3% of the population world-wide is infected globally. HCV belongs to the Hepacivirus genus of the Flaviviridae family and is transmitted through infectious blood or blood products. READ MORE

  7. 25. Development of vaccines and experimental models for chronic infections caused by the hepatitis C virus

    Author : Lars Frelin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HCV; chronic infection; DNA vaccine; NS3; viral vectors; transgenic mice;

    Abstract : The hepatitis C virus (HCV) is a major cause of chronic liver disease worldwide. It is estimated that HCV affects approximately 170 million people around the world. One feature of HCV infection is the high rate of viral persistence. READ MORE