Search for dissertations about: "NS5"

Showing result 1 - 5 of 8 swedish dissertations containing the word NS5.

  1. 1. Targeting Infectious Disease : Structural and functional studies of proteins from two RNA viruses and Mycobacterium tuberculosis

    Author : Anna M. Jansson; T. Alwyn Jones; Sherry L. Mowbray; E. Yvonne Jones; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; RNA virus; coronavirus; alphacoronavirus; nsp1; TGEV; flavivirus; Modoc virus; NS5; methyltransferase; mRNA capping; Mycobacterium tuberculosis; tuberculosis; 1-deoxy-D-xylulose 5-phosphate reductoisomerase; DXR; fosmidomycin analogues; MEP pathway; drug development; xray-crystallography; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Biokemi; Biochemistry; Medicinal Chemistry; Läkemedelskemi;

    Abstract : The recent emergence of a number of new viral diseases as well as the re-emergence of tuberculosis (TB), indicate an urgent need for new drugs against viral and bacterial infections.Coronavirus nsp1 has been shown to induce suppression of host gene expression and interfere with host immune response. READ MORE

  2. 2. Functional characterization of interactions between the flavivirus NS5 protein and PDZ proteins of the mammalian host

    Author : Karin Ellencrona; Magnus Johansson; Andrew Davidson; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Tick-borne encephalitis virus TBEV ; West-Nile virus WNV ; Dengue virus DENV ; flavivirus; PDZ domains; ZO-2; ZO-1; RIMS2; Scribble; Interferon; JAK-STAT signaling; PDZ array; virus-host protein interaction; Genetics; Genetik; molekylärgenetik; Molecular Genetics;

    Abstract : Flaviviruses are found all over the world and affect and infect millions of people every year. Flavivirus infection can lead to severe clinical outcomes resulting in neuronal damages e.g. Tick-borne encephalitis virus (TBEV), or severe hemorrhagic fevers e. READ MORE

  3. 3. Roles of mammalian Scribble in polarity signaling, virus offense and cell-fate determination

    Author : Michael Wigerius; Magnus Johansson; Lawrence Banks; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; cell polarity; scribble; tbev; RhoGTPase; jak-stat; mapk; neurite outgrowth; influenza a virus; Biochemistry; Biokemi; biokemi; Biochemistry;

    Abstract : Mammalian Scribble is a target for proteins encoded by human papilloma virus, retro- and flaviviruses. Tick-borne encephalitis virus (TBEV) is a flavivirus that have evolved distinct strategies to escape antiviral responses. READ MORE

  4. 4. Molecular characterization of the Tick-borne encephalitis virus : Environments and replication

    Author : Wessam Melik; Magnus Johansson; Sonja Best; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Tick-borne encephalitis virus; molekylärgenetik; Molecular Genetics;

    Abstract : The flavivirus genus is of major concern for world morbidity and mortality and includes viruses causing both encephalitic as well as hemorrhagic diseases. The incidence of Tick-borne encephalitis is increasing in many European countries and several reports have emphasized the expansion of the main vector, Ixodes ricinus. READ MORE

  5. 5. Nucleic acid-based detection and characterization of hepatitis C virus

    Author : Yun Zhibing; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; HCV; PCR; genotype; HVRI; heterogeneity; IFN-a; immunodeficiency;

    Abstract : GENERAL Nucleic acid-based methods weredeveloped to detect and characterizethe HCV genome in immunocompe-tent and immunodeficient pahents ofwhom some were IFN-a treated.HCV RNA was found in most sera(95%), livers (97%) and PBMC(100%) of patients with conflrmedchronic hepatitis, but also in sera(21%) of patients with indeterminateconfirmatory antibody test, especial-ly those with c22 antigen reactivity. READ MORE