Search for dissertations about: "NS5B polymerase"

Found 3 swedish dissertations containing the words NS5B polymerase.

  2. 1. Discovery and evaluation of direct acting antivirals against hepatitis C virus

    Author : Eldar Abdurakhmanov; Helena Danielson; David Frick; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Direct acting antivirals; Hepatitis C; NS3-4A protease; NS5B polymerase; structure-based drug discovery; fragment-based drug discovery; surface plasmon resonance; Biokemi; Biochemistry;

    Abstract : Until recently, the standard therapy for hepatitis C treatment has been interferon and ribavirin. Such treatment has only 50% efficacy and is not well tolerated. The emergence of new drugs has increased the treatment efficacy to 90%. READ MORE

  4. 2. Protein interactions involved in viral replication characterized by T7 phage display

    Author : Hamid Houshmand; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; protein-protein interaktion; fagdisplayteknik; HCV; polyomavirus; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

    Abstract : Protein interactions are essential for many cellular processes. By utilizing protein-protein interactions, viruses can infect their host cells and replicate. Phage display can be used for identification and characterization of protein-protein interactions. READ MORE

  5. 3. Reducing Attrition via Improved Strategies for Pre-clinical Drug Discovery : SPR-biosensor Aided Interaction Studies

    Author : Johan Winquist; Helena Danielson; Roderick E. Hubbard; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biokemi; Biochemistry;

    Abstract : The efficacy of a drug is tightly intertwined with its interaction mechanism with the drug target. The mechanism is dependent on the physicochemical and structural characteristics of both target and drug molecule.Drug discovery is plagued by a high attrition rate, whereas in the clinic, a major issue is drug resistance. READ MORE