Search for dissertations about: "NSC308848"

Found 1 swedish dissertation containing the word NSC308848.

2. 1. Targeting of the Myc pathway as a novel approach for cancer therapy

   Author : Hao Mo; Karolinska Institutet; Karolinska Institutet; []
   Keywords : oncogene; tumor suppressor gene; Myc; cellular screening; small molecules; MYRAs; NSC308848; camptothecin; paclitaxel; apoptosis; transcription; transformation.;

   Abstract : As transcription factors, Myc-family proteins function upstream of signaling pathways and regulate cell proliferation, differentiation, angiogenesis, apoptosis and transformation. Precisely regulated Myc expression is critical for cellular physiology, while perturbations of Myc expression have detrimental consequences to the organism. READ MORE