Search for dissertations about: "NSHDS"

Showing result 1 - 5 of 7 swedish dissertations containing the word NSHDS.

  2. 1. Molecular epidemiology approach : nested case-control studies in glioma and lymphoid malignancies

    Author : Florentin Späth; Beatrice S. Melin; Carl Wibom; Ann Sofie Johansson; Ingvar Bergdahl; Ola Landgren; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioma; B cell lymphoma; multiple myeloma; risk; repeated samples; prospective longitudinal study; nested case-control study; circulating sEGFR and sERBB2; circulating immune markers and growth factors; marker disease association; disease progression; NSHDS; Janus; linear mixed modeling; epidemiologi; Epidemiology; Oncology; onkologi;

    Abstract : BACKGROUND: Nested case-control studies aim to link molecular markers with a certain outcome. Repeated prediagnostic samples may improve the evaluation of marker-disease associations. However, data regarding the benefit of repeated samples in such studies are sparse. READ MORE

  4. 2. The CpG island methylator phenotype in colorectal cancer : studies on risk and prognosis

    Author : Anna Dahlin; Richard Palmqvist; Bethany van Guelpen; Maria Henriksson; Åke Öberg; Xiao-Feng Sun; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; DNA methylation; folate; microsatellite instability MSI ; prognosis; risk factors; t-lymphocytes; the CpG island methylator phenotype CIMP ; Vitamin B12; Pathology; Patologi; Tumour biology; Tumörbiologi; patologi; Pathology;

    Abstract : Background Colorectal cancer (CRC) is the second most common malignancy in developed countries. The mortality is high, with nearly half of patients dying from the disease. The primary treatment of CRC is surgery, and decisions about additional treatment with chemotherapy are based mainly on tumor stage. READ MORE

  5. 3. Lifestyle, biomarkers and the risk of developing inflammatory bowel disease

    Author : Lovisa Widbom; Johan Hultdin; Pontus Karling; Kim Ekblom; Kristina Stefansson; Andreas Münch; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammatory bowel disease; ulcerative colitis; Crohn s disease; smoking; cotinine; iron deficiency; ferritin; pyridoxal-5-phosphate; kynurenine pathway; Clinical Chemistry; klinisk kemi; invärtesmedicin; Internal Medicine;

    Abstract : Introduction: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic disease causing inflammation in the gut mucosa. The pathogenesis involves alteration in gut microbiota and in the intestinal barrier due to genetic factors, environmental exposure and dysregulation of the immune response. READ MORE

  6. 4. Dietary intake of naturally occurring plant sterols in relation to serum cholesterol and myocardial infarction - Epidemiological studies from Sweden and the UK

    Author : Sofia Klingberg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; plant sterols; dietary intake; food sources; serum cholesterol; CVD; myocardial infarction; nutrition; epidemiology;

    Abstract : Cardiovascular diseases (CVDs) are the leading cause of death in the world. High serum level of cholesterol is one of the major risk factors for CVD development. Serum levels of cholesterol can be modified by diet. READ MORE

  7. 5. Metabolic Risk Factors and Molecular Subtypes of Colorectal Cancer

    Author : Robin Myte; Bethany van Guelpen; Richard Palmqvist; Jenny Häggström; Matty Weijenberg; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; risk factors; metabolic syndrome; one-carbon metabolism; molecular subtypes; KRAS; BRAF; MSI; molecular pathological epidemiology; Cancer Epidemiology; cancerepidemiologi;

    Abstract : Background: Colorectal cancer (CRC) is a heterogeneous disease developing from distinct pathways, resulting in tumor subtypes with large differences in clinical and molecular characteristics. Molecular characteristics are increasingly being used clinically to guide therapy. READ MORE