Search for dissertations about: "Na K ATPase"

Showing result 11 - 15 of 64 swedish dissertations containing the words Na K ATPase.

2. 11. Functional significance of phosphorylation of rat renal Na+, K+-ATPase by PKA and PKC

   Author : Sam Xian Jun Cheng; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Na ; K -ATPase; protein phosphorylation; cAMP-dependent protein kinase; protein kinase C; site-directed mutagenesis; DNA transfection; isoproterenol; [Ca2 ]i.;

   Abstract : The activity of Na+,K+-ATPase (NKA) is short term regulated by hormones as well as by signalling pathways that involve activation of PKA or PKC, but the mechanism(s) remains unclear. This study was performed to evaluate whether this regulation of NKA occurs via PKA- or PKC-mediated phosphorylation of the NKA a subunit. READ MORE

4. 12. Manipulation of potassium ion fluxes to induce apoptosis in lung cancer cells

   Author : Britta Andersson; Kjell Grankvist; Parviz Behnam-Motlagh; Roger Henriksson; Ola Brodin; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apoptosis; Cisplatin; Intracellular K content; Mesothelioma; Na K ATPase pump; Clinical chemistry; Klinisk kemi;

   Abstract : Apoptosis is a special form of cell death that if non-functional may lead to diseases such as cancer. A reduction of the intracellular potassium ion (K+) content is necessary for activating enzymes important for the execution of apoptosis. READ MORE

5. 13. Canonical and noncanonical transducers for calcium signaling : role of Na,K-ATPase and angiotensin receptor

   Author : Zuzana Khorshidi; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Calcium (Ca2+) is the most universal and versatile signal in the cell. This versatility is based on the speed, amplitude and spatio-temporal patterning of the Ca2+ events. The inositol 1,4,5-trisphosphate receptor (IP3R) is one of the main Ca2+ channels responsible for the Ca2+ release from the intracellular stores. READ MORE

6. 14. Repurposing digitoxin in the treatment of pancreatic ductal adenocarcinoma : genotypic and phenotypic features as biomarkers for digitoxin sensitivity in vitro

   Author : Heléne Lindholm; Katarina Ejeskär; Ferenc Szekeres; Maria Faresjö; Sofie Mohlin; Högskolan i Skövde; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic ductal adenocarcinoma; Na K -ATPase; digitoxin; cardiac glycoside; metabolomics; choline; Translationell medicin TRIM; Translational Medicine TRIM;

   Abstract : The incidence of pancreatic ductal adenocarcinoma (PDAC) is increasing worldwide. The dismal prognosis and lack of effective treatments urges for increased research efforts in developing new treatment regimens. Since the development of new cancer treatments are expensive and time consuming, repurposing drugs is preferable when possible. READ MORE

7. 15. Regulation of Na+,K+-ATPase activity by protein phosphatase-1 and protein kinase C : studies in infant and adult renal tissue and on vascular smooth muscle cells

   Author : Dailin Li; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Na ; K -ATPase; phosphorylation; protein kinase C; protein phosphatase-1; arachidonic acid metabolites; ontogeny;

   Abstract : Na+, K+-ATPase is short-term modulated by hormones, involving activation of signal transduction system. The present study was designed to elucidate the role of the signaling molecules PP-1, PKC and arachidonic acid (AA) metabolites in the regulation of Na+, K+-ATPase by reversible phosphorylation, the final step of the signal transduction, and to examine the ontogeny of the signaling system. READ MORE