Search for dissertations about: "NanoSIMS"
Showing result 1 - 5 of 6 swedish dissertations containing the word NanoSIMS.
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1. Quantitative NanoSIMS provides subcellular concentration and distribution of oligonucleotide therapeutics
Abstract : Antisense oligonucleotides (ASOs) represent a powerful therapeutic modality that can selectively modulate gene expression. However, ASOs face two major hurdles that restrict their use in the clinic. The first issue is delivery of the ASO to a tissue of therapeutic interest while reducing exposure to unrelated tissues. READ MORE
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2. Quantitative chemical imaging to study content release from single nanovesicles
Abstract : Cellular communication is vital for the survival of multicellular organisms. This process often relies on a highly regulated mechanism called exocytosis, which involves the release of chemical signals. During exocytosis, vesicles can fully or partially release their contents. READ MORE
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3. PROBING SECRETORY VESICLES AND LIPOSOME MODEL SYSTEMS USING NANOSCALE ELECTROCHEMISTRY AND MASS SPECTROMETRY
Abstract : Cellular communication is based on the process of exocytosis, regulated release of chemical messengers into the extracellular space. These messengers, neurotransmitters, are packed into vesicles that during exocytosis fuse with the plasma membrane and release their content. READ MORE
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4. Multimodal Chemical Imaging of Amyloid Plaque Pathology in Alzheimer’s Disease
Abstract : Alzheimer’s disease (AD) is the most common form of dementia. AD has been linked to the aggregation of amyloid beta (Aβ) peptides into extracellular deposits, Aβ plaques. These are also found in cognitively unimpaired amyloid-positive (CU-AP) individuals, but these Aβ plaques are primarily diffuse in structure. READ MORE
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5. Correlative Chemical Imaging of Nanoscale Subcellular Structures
Abstract : Chemical imaging can elucidate complex mechanisms, relationships, and components of biological samples. For example, it can reveal properties such as chemical composition, chemical structure, reactivity, and topography. Several imaging techniques exist, each providing different types of information. READ MORE