Search for dissertations about: "Nasal mucosa"
Showing result 1 - 5 of 64 swedish dissertations containing the words Nasal mucosa.
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1. Olfactory Transfer of Analgesic Drugs After Nasal Administration
Abstract : Nasal administration of analgesics for achieving rapid pain relief is currently a topic of great interest. The blood-brain barrier (BBB) restricts access to the central nervous system (CNS) for several central-acting drugs, such as morphine and dihydroergotamine, which results in a substantial effect delay. READ MORE
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2. Topical formulations, design and drug delivery : "A dive into water"
Abstract : Water is a vital component regulating the properties of topical formulations and their interaction with biological barriers, such as skin and mucosa. Changing the watercontent within the frame of the pharmaceutical triangle will have a huge impact on which type of formulation, such as a cream, ointment, gel, or lotion, is formed, as well as the physical properties of the formulation. READ MORE
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3. Nasal Drug Delivery : In Vitro Studies on Factors Influencing Permeability and Implications on Absorption
Abstract : Nasal delivery is a feasible alternative to oral or parenteral administration for some drugs because of the high permeability of the nasal epithelium, rapid drug absorption across this membrane and avoidance of hepatic first-pass metabolism. The main objective of this thesis was to investigate factors influencing the permeability of the nasal mucosa to various compounds and to evaluate implications for drug absorption via the nasal route. READ MORE
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4. Tissue-Selective Activation and Toxicity of Substituted Dichlorobenzenes : Studies on the Mechanism of Cell Death in the Olfactory Mucosa
Abstract : The nasal passages are constantly exposed to both air- and bloodborne foreign compounds. In particular, the olfactory mucosa is demonstrated to be susceptible to a variety of drugs and chemicals. READ MORE
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5. Silicone obturators and the bacterial flora in symptomatic nasal septal perforations
Abstract : Background A perforation in the nasal septum can cause symptoms such as bleeding, obstruction, crusts and pain, and can be a challenge to treat. Surgery is the treatment of choice, but disease, size of the perforation, or the patient’s wish may contradict surgery. READ MORE