Search for dissertations about: "Natalia Borg"

Found 1 swedish dissertation containing the words Natalia Borg.

2. 1. Distribution of antiviral nucleoside analogues into brain and skin

   Author : Natalia Borg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The aim of this thesis was to study physiological and physico-chemical factors influencing the pharmacokinetics and distribution over the blood-brain barrier of antiviral nucleoside analogues in the rat, and to study the distribution to the human skin in vivo of an anti-herpetic nucleoside analogue. Microdialysis was used to sample the free (unbound) extracellular concentration of the nucleoside analogues from the brain tissue, muscle and blood in the rat and from the dermis of healthy human volunteers. READ MORE