Search for dissertations about: "Natalia Issaeva"
Found 1 swedish dissertation containing the words Natalia Issaeva.
University dissertation from Stockholm : Karolinska Institutet, Microbiology and Tumor Biology Center (MTC)
Abstract : Lesions in the p53 pathway that inactivate p53 tumor suppression function occur with extremely high frequency in cancer, targeting almost all tumors regardless of patient age or tumor type. This study is aimed at developing approaches for the selective elimination of tumors carrying defects in the p53 pathway, namely protection of p53 from degradation by its own destructor HDM2 in wild type p53-carrying tumors and refolding of p53 by small molecules in mutant p53-containing tumors. READ MORE