Search for dissertations about: "Natalie Landeck"

Found 1 swedish dissertation containing the words Natalie Landeck.

2. 1. Pathogenic effects of alpha-synuclein: modifications and toxicity

   Author : Natalie Landeck; Brain Repair and Imaging in Neural Systems (BRAINS); []
   Keywords : Parkinson s disease; adeno-associated viral vector; animal models; alpha-synuclein; substantia nigra; dopaminergic neurons; phosphorylation; aggregation; toxicity;

   Abstract : Accumulation of intraneuronal inclusions, containing mainly a protein called alpha-synuclein (asyn), is thought to play a critical role in neurodegenerative disorders such as Parkinson's disease (PD). In these so called Lewy bodies, the majority of asyn is phosphorylated at serine 129 (pS129) suggesting that post-translational modifications may play a critical role in the process of aggregate formation. READ MORE