Search for dissertations about: "Natural Sciences Biological Sciences Biochemistry and Molecular Biology"
Showing result 1 - 5 of 1026 swedish dissertations containing the words Natural Sciences Biological Sciences Biochemistry and Molecular Biology.
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1. Evolutionary and Pharmacological Studies of NPY and QRFP Receptors
Abstract : The neuropeptide Y (NPY) system consists of 3-4 peptides and 4-7 receptors in vertebrates. It has powerful effects on appetite regulation and is involved in many other biological processes including blood pressure regulation, bone formation and anxiety. READ MORE
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2. Influences of in vivo and in vitro loading on the proteoglycan synthesis of articular cartilage chondrocytes
Abstract : In this study, the biosynthesis of proteoglycans (PGs) was examined in articular cartilage of canine hip joint after long-distance running experiment and in bovine chondrocyte cultures during in vitro loading with hydrostatic pressure. In addition, new assays were developed for more sensitive quantitation of glycosaminoglycans (GAGs) and PGs. READ MORE
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3. Sperm Membrane Channels, Receptors and Kinematics : Using boar spermatozoa for drug toxicity screening
Abstract : Internal fertilization usually implies that a spermatozoon, with intact attributes for zygote formation, passes all hurdles during its transport through the female genitalia and reaches the oocyte. During this journey, millions to billions of other spermatozoa perish. READ MORE
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4. On Transcriptome Sequencing
Abstract : This thesis is about the use of massive DNA sequencing to investigate the transcriptome. During recent decades, several studies have made it clear that the transcriptome comprises a more complex set of biochemical machinery than was previously believed. READ MORE
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5. High-throughput screening using multicellular tumor spheroids to reveal and exploit tumor-specific vulnerabilities
Abstract : High-throughput drug screening (HTS) in live cells is often a vital part of the preclinical anticancer drug discovery process. So far, two-dimensional (2D) monolayer cell cultures have been the most prevalent model in HTS endeavors. However, 2D cell cultures often fail to recapitulate the complex microenvironments of in vivo tumors. READ MORE
