Search for dissertations about: "Ncf1"

Showing result 1 - 5 of 17 swedish dissertations containing the word Ncf1.

  2. 1. The Role of Reactive Oxygen Species in Animal Models of Autoimmunity

    Author : Malin Hultqvist; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mice; Phytol; ROS; NOX; NADPH; p47phox; Ncf1; EAE; inflammation; Arthritis; RA; MS; Rats; Autoimmunity;

    Abstract : Reactive oxygen species (ROS) produced by the phagocyte NADPH oxidase complex are important in the killing of invading pathogens. Lately, a role of ROS has been suggested in regulation of the immune system. READ MORE

  4. 2. Identification of Arthritis Regulating Genes in Rats

    Author : Peter Olofsson; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; serologi; transplantation; Clinical genetics; Klinisk genetik; serology; Immunology; QTL; RA; Epistasis; Ncf1; Linkage; PIA; Arthritis; Rat;

    Abstract : The immune response is designed to protect the body from harmful microbial invasions. However, when the immune system attacks itself instead, an autoimmune reaction starts that damage our own cells, tissues and organs. READ MORE

  5. 3. Oxidative regulation of NCF1 in B cells and mouse models of arthritis

    Author : Ana do Carmo Oliveira Coelho; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Autoimmune diseases (ADs) are chronic pathologies that result from a dysregulation of autoreactive B and T cells leading to autoantibody production and ultimately destruction of self. In paper I, we studied inflammation associated with autoimmunity. READ MORE

  6. 4. Reduced ROS production triggers arthritis / The role of T cells in arthritis pathogenesis

    Author : Jens Holmberg; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Spleen and lymph nodes Inflammation Reactive oxygen species T cells MHC; serology; Immunology; Immunologi; serologi;

    Abstract : The aim of this thesis is to defend a novel mechanism that triggers arthritis susceptibility in both rats and mice through reduced production of reactive oxygen species (ROS), but also to introduce a novel model for chronic relapsing arthritis. Five papers are included, all of which employ animal models for rheumatoid arthritis and one that also uses animal models for multiple sclerosis. READ MORE

  7. 5. The role of macrophages in regulating inflammation by oxidative burst

    Author : Angela Pizzolla; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The production of reactive oxygen species (ROS) through a process called oxidative burst is an essential defence mechanism against pathogens. In phagocytes, such as neutrophils and macrophages, the NADPH oxidase 2 (NOX2) complex is the main source of ROS. READ MORE