Search for dissertations about: "Neoantigens"

Showing result 1 - 5 of 7 swedish dissertations containing the word Neoantigens.

  2. 1. Computational analysis on the effects of variations in T and B cells. Primary immunodeficiencies and cancer neoepitopes

    Author : Gabriel Ndipagbornchi Teku; Proteinbioinformatik; []
    Keywords : Network topology; Network dynamics; network modeling; Network Simulation; T cells; B cells; Neoepitopes; Neoantigens; cancer;

    Abstract : Computational approaches are essential to study the effects of inborn and somatic variations. Results from such studies contribute to better diagnosis and therapies. Primary immunodeficiencies (PIDs) are rare inborn defects of key immune response genes. Somatic variations are main drivers of most cancers. READ MORE

  4. 2. Harnessing T cell immunity for the prevention and treatment of liver cancer

    Author : Panagiota Maravelia; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hepatocellular carcinoma (HCC) accounts for more than 80% of all diagnosed cases of liver cancer which is a major cause of cancer related fatalities worldwide. With few improvements in the survival rates during the last decades, prevention of HCC is key in reducing its burden globally. READ MORE

  5. 3. Multi-omics analysis of relapsed acute myeloid leukemia

    Author : Svea Stratmann; Linda Holmfeldt; Caroline Heckman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia AML ; relapse and resistance; next generation sequencing WGS WES ; RNA-sequencing; DNA methylation; HiRIEF LC-MS; proteogenomics; Molekylär medicin; Molecular Medicine;

    Abstract : The prognosis for patients suffering from acute myeloid leukemia (AML) remains unsatisfactory and survival is often measured in months. Although the majority of patients achieve complete remission after aggressive treatment, most of them relapse within a few years. READ MORE

  6. 4. Characterization and targeting of leukemia propagating cells

    Author : Stina Virding Culleton; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Patients with hematopoietic malignancies have a large, unmet medical need. Allogeneic hematopoietic stem cell transplantation remains the only curative option, but many patients are not eligible for such treatment. READ MORE

  7. 5. MHC-class I restricted peptide-based immunomodulation of CD8+ T and NK cells

    Author : Adil Doganay Duru; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The main aims of the immune system are to protect the host from potential threats by distinguishing self from non-self and altered-self. T cells and NK cells play a key role in the identification and elimination of threats by scanning a repertoire of peptide epitopes presented by major histocompatibility complex (MHC) molecules. READ MORE