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Showing result 1 - 5 of 9 swedish dissertations matching the above criteria.

  2. 1. Evidence and context : knowledge translation for newborn health in low-income settings

    Author : Anna Bergström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Neonatal hypothermia;

    Abstract : Background: Neonatal mortality (death within the first 28 days of life), presently accounts for 41% of the global burden of under-5 deaths. Estimates indicate that about two-thirds of the 3.1 million neonatal deaths could be averted with an increased implementation of existing evidence-based practices. READ MORE

  4. 2. Neonatal hypoxic ischemic encephalopathy : inflammation and therapies

    Author : Elena Di Martino; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Neonatal hypoxic ischemia (HI) is a severe condition characterized by a complex pathophysiology. The lack of oxygen (hypoxia) and blood flow (ischemia) leads to neuronal cell death via necrosis and apoptosis, and a consequent post-ischemic inflammation. HI brain injury may lead to seizures, cognitive and motor impairments, and death. READ MORE

  5. 3. Apoptotic mechanisms in the neonatal brain following hypoxia-ischemia

    Author : Ylva Carlsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypoxia-ischemia brain caspase-2 cyclophilin D MLK neonatal.;

    Abstract : Neonatal encephalopathy is often perinatally acquired and caused by hypoxia-ischemia (HI). Brain injury develops with a delay, over 12-48 hours, after the insult. Hypothermia, an established neuroprotective treatment, saves 1 infant in 9 from neurological deficits suggesting that there is room for further improvement. READ MORE

  6. 4. Hypoxic ischemic encephalopathy : diagnosis, hypothermia treatment and outcome

    Author : Boubou Hallberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hypothermia treatment (HT) is now proven to be neuroprotective, is associated with favourable outcomes, and is considered as the standard of care for moderate to severe hypoxic ischemic encephalopathy (HIE). The treatment should be regionalized with a minimum of ten treated infants per year with regard to securing patient safety, staff training, development and future research. READ MORE

  7. 5. Long-term outcome after hypothermia-treated hypoxic-ischaemic encephalopathy

    Author : Katarina Robertsson Grossmann; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hypoxic-ischaemic encephalopathy (HIE) is a major cause of acquired brain injury in newborn infants. It is a potentially life-threatening condition that leaves survivors at substantial risk of life-long debilitating sequelae including cerebral palsy, epilepsy, intellectual disability, sensory disruption, behavioural issues, executive difficulties and autism spectrum disorder. READ MORE