Search for dissertations about: "Neural Crest Stem Cells"

Showing result 16 - 20 of 26 swedish dissertations containing the words Neural Crest Stem Cells.

  2. 16. FoxF genes in development and disease

    Author : Seyed Ali Moussavi Nik; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; FOXF1; Sfrp1; LGR5 stem cells; Tgfb; Wnt signaling; ECM; Intact intestinal epithelium; Foxf2; ACDMPV;

    Abstract : Forkhead transcription factors of the FoxF group are important during embryonic de-velopment, and mutation of either of the members, Foxf1 and Foxf2, has fatal conse-quences. In this thesis, I present our recent findings about the mechanism of action of FoxF genes in development and disease. READ MORE

  4. 17. Stem cell transplantation and regeneration after dorsal root avulsion

    Author : Carl Trolle; Elena Kozlova; Adam Reid; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Regeneration; dorsal root; sensory nerve; nerve injury; cell transplantation; Medical Science; Medicinsk vetenskap;

    Abstract : Spinal root avulsion leads to paralysis and loss of sensory function. Surgical methods can improve motor function and ameliorate pain but sensory recovery in adults is poor. Previous studies have shown that cell transplantation or treatment with trophic factors can improve functional outcome in rodents after dorsal root transection or crush. READ MORE

  5. 18. Optimization and validation of a species-specific in vivo approach for studies on growth and progression of neural crest derived tumours

    Author : Jessica Cedervall; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Despite great advantages in cancer therapeutics during the last decades, therapy-resistance remains a problem in the majority of malignancies. Hence, development of more effective therapeutics is critical to enhance survival of patients with cancer. READ MORE

  6. 19. Study of the Proliferation, Function and Death of Insulin-Producing Beta-Cells in vitro: Role of the Transcription Factor ZBED6

    Author : Xuan Wang; Nils Welsh; Nils Billestrup; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ZBED6; Pancreatic beta-cell; Proliferation; Insulin secretion; Apoptosis; Adhesion; Medical Science; Medicinsk vetenskap;

    Abstract : A thorough understanding of beta-cell proliferation, function, death and regeneration under normal condition as well as in the progression of diabetes is crucial to the conquest of this disease. The work presented in this thesis aimed to investigate the expression and role of a novel transcription factor, Zinc finger BED domain-containing protein 6 (ZBED6), in beta-cells. READ MORE

  7. 20. Nestin regulation in the embryonic and adult CNS

    Author : Carina Lothian; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The developing mammalian central nervous system (CNS), i.e. the brain and spinal cord, is generated from neuroectodermal stem/progenitor cells lining the neural tube. The CNS stem/progenitor cells proliferate and migrate to give rise to the three principal cell types in the developing CNS: neurons, astrocytes and oligodendrocytes. READ MORE