Search for dissertations about: "Neural tube defects"

Showing result 1 - 5 of 11 swedish dissertations containing the words Neural tube defects.

  1. 1. Pluripotent Stem Cells of Embryonic Origin Applications in Developmental Toxicology

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Måns Jergil; Uppsala universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Embryonic stem cell; Microarray; Toxicogenomics; Valproic acid; Developmental toxicology; Teratogenicity; Neural tube defects; Histone deacetylase inhibitor; In vitro toxicology; PHARMACY Toxicology; FARMACI Toxikologi; Toxicology; Toxikologi;

    Abstract : General toxicity evaluation and risk assessment for human exposure is essential when developing new pharmaceuticals and chemicals. Developmental toxicology is an important part of this risk assessment which consumes large resources and many laboratory animals. READ MORE

  2. 2. Transcriptomics and Proteomics Applied to Developmental Toxicology

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Kim Kultima; Uppsala universitet.; [2007]
    Keywords : Toxicology; 2D-DIGE; Valproic acid; PBDE-99; Flame retardant; Neural tube defects; Microarray; In vivo; In vitro; Biomarker; Brain growth spurt; Normalization; Mouse embryo; Toxicogenomics; Toxikologi;

    Abstract : Developmental toxicology is an important part of preclinical drug toxicology as well as environmental toxicology. Assessing reproductive and developmental toxicity is especially expensive and time demanding, since at least two generations of animals are needed in the tests. READ MORE

  3. 3. Altered embryonic environment and congenital malformations in diabetic pregnancy

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Parri Wentzel; Uppsala universitet.; [1997]
    Keywords : Abnormalities *etiology prevention control; Animals; Diabetes Mellitus; Experimental *pathology; Dietary Supplements; Female; Folic Acid *therapeutic use; Glucose *toxicity; Neural Tube Defects etiology prevention control; Pregnancy; Pregnancy in Diabetics *physiopathology; RNA genetics isolation purification; Rats; Research Support; Non-U.S. Gov t; Tail abnormalities embryology;

    Abstract : .... READ MORE

  4. 4. Early function of KCC2 and wnt genes : Cytoskeletal effects in neural stem cells

    University dissertation from Stockholm : Karolinska Institutet, Department of Women's and Children's Health

    Author : Zachi Horn; Karolinska Institutet.; Karolinska Institutet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : From closure of the neural tube until formation of neuronal networks, cells undergo several crucial changes which depend on the expression of many important molecules. GABA, the principal inhibitory neurotransmitter in the adult nervous system, acts as an excitatory signal during embryonic development. READ MORE

  5. 5. Cytoskeleton-interacting proteins in brainstem development : Roles of KCC2 and Vangl2

    University dissertation from Stockholm : Karolinska Institutet, Dept of Women's and Children's Health

    Author : Zachi Horn; Karolinska Institutet.; Karolinska Institutet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The brainstem is the most evolutionary conserved division of the brain. It develops from the hindbrain and midbrain regions of the neural tube and forms neural networks that regulate vital functions of the body. One of the most critical roles is to generate respiratory rhythm for the regulation of oxygen, carbon dioxide and pH levels. READ MORE