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Showing result 1 - 5 of 8 swedish dissertations matching the above criteria.

  2. 1. Neuro-immuno-regulation of inflammation in the colonic mucosa : Focus on mast cells and eosinophils in bowel disorders

    Author : Maria Teresa Casado Bedmar; Åsa Keita; Johan D Söderholm; Marie Carlson; Melanie Gareau; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mast cells; Eosinophils; Vasoactive intestinal polypeptide; Neuro-immune; Intestinal barrier; Irritable bowel syndrome; Inflammatory bowel diseases; Ussing chamber; Advance image analysis;

    Abstract : Intestinal homeostasis is key to control uptake across the mucosa and protect from harmful substances. Disturbances in the bidirectional communication between the gut and the brain are implicated in irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD), being Crohn’s disease (CD) and ulcerative colitis (UC) the two most common IBD subtypes. READ MORE

  4. 2. Neuro-immune communication: role of the vagus nerve : an electrophysiological study

    Author : Violeta Bucinskaite; Karolinska Institutet; Karolinska Institutet; []
    Keywords : cholecystokinin; CCKA; CCKB; cytokines; IL-1[beta]; illness; nerve activity; NIDDM; OLETF; the vagus; vagotomy;

    Abstract : Defence mechanisms involve close interactions between the nervous and immune systems following an immune challenge. The vagal pathways which modulate major visceral functions under normal conditions are also important neural pathways for the transmission of information on peripheral conditions to the CNS. READ MORE

  5. 3. Role of prostaglandin E2 as a neuro-immune mediator in the cholinergic anti-inflammatory pathway

    Author : Priya Revathikumar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Therapeutic implications of cholinergic anti-inflammatory pathway (CAP) activation have marked the beginning of a novel treatment strategy of passing electrical impulses along the left vagus nerve to alleviate acute and chronic inflammatory conditions. Extensive work in understanding CAP through vagus nerve stimulation (VNS) have identified key molecular and cellular mechanisms involved in the α7 nicotinic acetylcholine receptor (nAChR) mediated control of inflammation. READ MORE

  6. 4. Neuro-immune regulation of macromolecular permeability in the normal human colon and in ulcerative colitis

    Author : Conny Wallon; Johan Dabrosin Söderholm; Peter Naredi; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colitis; ulcerative; colon; sigmoid; cytology; immunohistochemistry; Gastroenterology; Gastroenterologi;

    Abstract : Background and aim: Persistent stress and life events affect the course of ulcerative colitis (UC) by largely unknown mechanisms. Regulation of epithelial permeability to antigens is crucial for the balance between inflammation and immuno-surveillance, and increased intestinal permeability has been shown in patients with ulcerative colitis. READ MORE

  7. 5. The dynamics of intra- and inter-organ communication during an acute kidney infection

    Author : Svava Steiner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis focuses on the roles of neuro-immune communication and infection-mediated coagulation during bacterial kidney infections. We demonstrate dynamic intra- and inter-organ host responses, where the outcome of an infection depends on both bacterial and host factors. READ MORE