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Showing result 1 - 5 of 150 swedish dissertations matching the above criteria.

2. 1. Studies of Spinal Motor Control Networks in Genetically Modified Mouse Models

   Author : Henrik Gezelius; Klas Kullander; Ted Ebendal; Martyn Goulding; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acetyl choline; central nervous system; central pattern generator; Cre recombinase; development; genetic screen; glutamate; interneuron; motor neuron; mouse; mouse genetics; movement; network; neuronal network; nicotinic receptors; physiology; Renshaw cell; rhythm; spinal cord; transmitter; Neuroscience; Neurovetenskap; Neurobiology; Neurobiologi; Molecular neurobiology; Molekylär neurobiologi; Neurophysiology; Neurofysiologi; Neurobiology; Neurobiologi; medicinsk utvecklings- och neurobiologi; Developmental Neurosciences;

   Abstract : Spinal neurons are important in several aspects motor control. For example, the neurons essential for locomotor movements reside in the ventral spinal cord. In this thesis, different motor control functions are being related to neuronal populations defined by their common expression of a gene. READ MORE

4. 2. Positron Emission Tomography (PET) Studies in Anxiety Disorders

   Author : Åsa Michelgård Palmquist; Mats Fredrikson; Lars von Knorring; Hans Ågren; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Positron emission tomography; PET; amygdala; fear; anxiety; anxiety disorders; specific phobia; social phobia; posttraumatic stress disorder; PTSD; regional cerebral blood flow; rCBF; substance P; SP; neurokinin 1 receptor; NK1; GR205171; STAI-S; Psychiatry; Psykiatri; Neurobiology; Neurobiologi; Neuroscience; Neurovetenskap; Experimental brain research; Experimentell hjärnforskning; Molecular neurobiology; Molekylär neurobiologi; Radiation biology; Strålningsbiologi; Neurobiology; Neurobiologi; Neurobiology; Neurobiologi;

   Abstract : Anxiety disorders are very common and the primary feature is abnormal or inappropriate anxiety. Fear and anxiety is often mediated by the amygdala, a brain structure rich in substance P (SP) and neurokinin 1 (NK1) receptors. READ MORE

5. 3. Generation of Dopaminergic Neurons from Human Embryonic Stem Cells

   Author : Tandis Vazin; Joakim Lundeberg; Ernest Arenas; KTH; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human; dopaminergic; embryonic stem cells; differentiation; stromal cells; PA6 cells; dopamine; neurons; Neuroscience; Neurovetenskap; Neurobiology; Neurobiologi; Molecular neurobiology; Molekylär neurobiologi;

   Abstract : Since the first successful derivation of human embryonic stem cells (hESC), rapid progress has been attained in the development of strategies in differentiation of these cells into various neural lineages, with the fundamental objective of using these cells for replacement and repair of damaged neuronal circuits in the central nervous system (CNS). Of particular interest are midbrain dopaminergic (mDA) neurons, which play a central role in regulation of voluntary movement. READ MORE

6. 4. Strategies in the rat gambling task : Individual differences in decision-making and associations to behavior, neurobiology and human strategies

   Author : Nikita Tjernström; Erika Roman; Barry Everitt; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Behavior; copulatory test; decision-making; ethanol; gambling disorder; impulsivity; individual differences; Iowa gambling task; MALDI-MSI; multivariate concentric square field; neurobiology; novel cage; opioid antagonist; rat gambling task; resting-state fMRI; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Gambling disorder (GD) is a behavioral addiction characterized by persistent and recurrent gambling behavior that disrupts personal, social or professional life. Studies have revealed that GD shares many features with alcohol and substance use disorders, but little is known about potential unique features in GD and to what extent characteristics are shared. READ MORE

7. 5. Phosphoproteomics to tackle brain disorders : Insight into the murine brain phosphoproteome

   Author : Valentina Siino; Institutionen för immunteknologi; []
   Keywords : Phosphoproteomics; mass spectrometry; brain disorders; neurobiology; phosphorylation;

   Abstract : Brain disorders affect the normal functionality of the brain causing inability in controlling certain behaviours. In the last two decades, despite the technological advancement, many biological questions concerning brain mechanisms and neural networks remain still unclear. READ MORE