Search for dissertations about: "Neuroblastoma SH-SY5Y cells"

Showing result 16 - 20 of 38 swedish dissertations containing the words Neuroblastoma SH-SY5Y cells.

  2. 16. Expression and regulation of steroid metabolizing enzymes in cells of the nervous and skeletal systems : Special focus on vitamin D metabolism

    Author : Mokhtar Almokhtar; Maria Norlin; Kjell Wikvall; Gösta Eggertsen; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Little is known about the mechanisms of vitamin D actions in the brain and bone. In this study, the metabolism of vitamin D and its regulation in various cell cultures of the nervous and skeletal systems were examined. READ MORE

  4. 17. Cell interactions in the CNS and their consequences for neuronal apoptosis

    Author : Mikaela Berglund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Aggregate cultures; apoptosis; automated image analysis; cytochrome c; interactions; JNK; microglia; neuron; neural precursor cells; rotenone; UV.;

    Abstract : The central nervous system consists of an intricate network of neurons and glial cells that depend on reciprocal communication to develop and maintain the vital functions of the brain. if the balance is disturbed by injury or disease, two cell types in particular, microglia and astrocytes, respond by producing factors that help combat the infection or delimit the affected area. READ MORE

  5. 18. Investigation on Pre- and Postsynaptic Ca2+ Signaling in Neuronal Model Systems

    Author : Jelena Krjukova; Åkerman Karl; Kukkonen Jyrki; Rydqvist Bo; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; calcium; neurotransmitter release; nicotine; depolarization; G-protein coupled receptor; muscarinic; phospholipase C; m-3M3FBS; Fysiologi; Physiology; Fysiologi;

    Abstract : Communication between neuronal and non-neuronal is called volume transmission when the released neurotransmitter (NT) acts via diffusion and affects several target cells. Both the neurosecretory and postsynaptic cell responses are linked to [Ca2+]i elevations. READ MORE

  6. 19. Cell death and signal transduction pathways in Alzheimer's disease : the role of presenilin 1

    Author : Bogdan O Popescu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mutated presenilins (PSs) may cause familial Alzheimer's disease (FAD) by altering neuronal signal transduction pathways, by increasing AP production or by triggering a number of proapoptotic mechanisms. The present thesis explores mechanisms by which PSs regulate signal transduction and cell death with relevance to AD. READ MORE

  7. 20. Age dependent beta-amyloid isoforms and implications of different drug treatments as studied in different transgenic mouse models and cell lines

    Author : Tamanna Mustafiz; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The Amyloid-β (Aβ) peptide is the main component of the the amyloid plaques in Alzheimer’s Disease (AD) and has been implicated to be the cause of the disease. During the last decade it has become increasingly evident that soluble, oligomeric forms of Aβ are more toxic to neurons than the plaques and might play an important role in the disease pathogenesis. READ MORE