Search for dissertations about: "Neuroblastoma SH-SY5Y cells"

Showing result 21 - 25 of 38 swedish dissertations containing the words Neuroblastoma SH-SY5Y cells.

  2. 21. Steroids and steroid-metabolizing enzymes in the nervous system : Special focus on cell survival and sex hormone synthesis

    Author : Ida Emanuelsson; Maria Norlin; Kjell Wikvall; Lena Ekström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biokemi; Biochemistry;

    Abstract : Some steroids in the brain and peripheral nervous system have been shown to have neuroprotective effects but the knowledge is limited. The present study examines the effects of steroids including oxysterols, vitamin D and vitamin D analogs on cell viability/growth and steroidogenesis in the nervous system. READ MORE

  4. 22. Alzheimer's disease mutations and cellular signalling

    Author : Monika Vestling; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer's disease is the most frequent cause of dementia in elderly and is characterised neuropathologically by the extracellular deposition of amyloid plaques (containing the 39-43 amino acid Abeta peptide), as well as intracellular neurofibrillary tangles (NFTs) composed primarily of an abnormally hyperphosphorylated form of the microtubule-associated protein tau. A proportion (10- 15%) of Alzheimer's disease cases is familial, the remainder being sporadic. READ MORE

  5. 23. Evaluation of neurotoxic properties of gliotoxin

    Author : Viktoria Axelsson; Anna Forsby; Marion Ehrich; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mycotoxin; gliotoxin; A. fumigatus; cytotoxicity; neurotoxicity; Neurochemistry; Neurokemi;

    Abstract : The occurrence of mould in food and animal feed is a severe problem due to the secondary metabolites, called mycotoxins, which can possess toxic activity. Aspergillus fumigatus is a common fungus found in improperly stored animal feed and the abundance of spores of the fungus is frequently spread into the air. READ MORE

  6. 24. Alzheimer´s disease-related amyloid precursor protein and presenlin genes : normal function and pathophysiology

    Author : Fiona Flood; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer's disease (AD) is characterised neuropathologically by the presence of plaques and tangles in the brain. AD can be sub-grouped into early onset (EOAD, age of onset ... READ MORE

  7. 25. The involvement of degradation pathways and neuron-to-neuron transmission in Alzheimer’s disease

    Author : Lotta Agholme; Martin Hallbeck; Katarina Kågedal; Jan Marcusson; Gunnar Gouras; Linköpings universitet; []
    Keywords : ;

    Abstract : Although the vast majority of Alzheimer’s disease (AD) cases are of the sporadic type, mutations causing the familial form have been the focus of AD research for decades. The disease is pathologically characterised by β-amyloid (Aβ) and tau protein aggregates in neuritic plaques and neurofibrillary tangles. READ MORE