Search for dissertations about: "Neuroblastoma tumour"

Showing result 1 - 5 of 34 swedish dissertations containing the words Neuroblastoma tumour.

2. 1. Microenvironmental Impact on Tumour Cell Phenotype and Genotype in Adult and Paediatric Tumours

   Author : Hiroaki Yasui; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer genotype; cancer phenotype; malignant rhabdoid tumour; neuroblastoma; ovarian cancer; tumour evolution; Wilms tumour;

   Abstract : This thesis explores how the tumour microenvironment affects the phenotype and shapes the evolution of cancer cells. It encompasses four separate studies:First, we explored the effect of chemokines on the peritotumoral microenvironment of ovarian cancer. READ MORE

4. 2. Gene therapy of neuroblastoma

   Author : Yvonne Arvidsson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroblastoma; gene therapy; PNP; ASK1; MASH1; IL-12; GM-CSF; immunotherapy; apoptosis.;

   Abstract : Aims: The survival of children with advanced stages of neuroblastoma has not improved significantly during recent years. Therefore additional treatments based on other modalities need to be developed. The objective of this thesis was to investigate the possibility to develop gene therapy of neuroblastoma. READ MORE

5. 3. Genomic instability and genetic heterogeneity in neuroblastoma tumours

   Author : Niloufar Javanmardi; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma tumour; subclone; mutation; relapse; deep sequencing; tumour supressor gene;

   Abstract : Neuroblastoma (NB), a tumour of the sympathetic nervous system and the most common malignant disease of early childhood, is responsible for 9% of paediatric cancer related deaths. Aggressive NB still constitutes a major clinical problem with survival rates of about 35%. READ MORE

6. 4. Polyamine analogues inhibit neuroblastoma cell growth

   Author : Erika Söderstjerna; Biologiska institutionen; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; survivin; cell cycle; polyamine analogue; polyamines; apoptosis; neuroblastoma; MYCN;

   Abstract : Abstract Neuroblastoma is a highly malignant neoplasm found in children. Although children with high-risk neuroblastoma respond to chemotherapy, relapses are common and an estimated long-time survival prognosis is approximately 15%. Thus, there is a tremendous need for new chemotherapeutic drugs for the treatment for neuroblastoma. READ MORE

7. 5. Exploring novel therapeutic strategies in neuroblastoma

   Author : Joanna Szydzik; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Neuroblastoma; Anaplastic Lymphoma Kinase; Targeted therapy; ATR inhibition;

   Abstract : Neuroblastoma (NB) is the most frequently diagnosed extracranial tumour in children, which arises from transient embryonal tissue of the neural crest that fails to complete terminal differentiation into neurons. Even after completion of successful therapy, high risk neuroblastoma patients typically suffer from post-treatment induced toxicity which impacts on their ability to lead a normal life. READ MORE