Search for dissertations about: "Neurochemistry and Molecular Neurobiology"

Showing result 1 - 5 of 74 swedish dissertations containing the words Neurochemistry and Molecular Neurobiology.

  1. 1. Cell-penetrating peptides in protein mimicry and oligonucleotide delivery Applications and mechanisms

    University dissertation from Stockholm : Institutionen för neurokemi

    Author : Henrik Johansson; Ülo Langel; Michael Gait; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peptide; oligonucleotide; cell-penetrating peptide; PNA; splicing; MEDICINE Chemistry Neurochemistry; MEDICIN Kemi Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Abstract : The plasma membrane functions as a barrier, restricting entry of hydrophilic pharmaceutical agents. Cell-penetrating peptides (CPPs) are capable of transporting bioactive cargos into the cell and have consequently been extensively investigated for their mechanism of entry and capability to deliver various cargos spanning from peptides to plasmids. READ MORE

  2. 2. The amyloid-β precursor protein (APP) and its adaptor protein Fe65 Two key players in Alzheimer’s disease

    University dissertation from Stockholm : Department of Biochemistry and Biophysics, Stockholm University

    Author : Preeti Menon; Anna-Lena Ström; Thorsten Müller; [2020]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; APP; Fe65; Meprinβ; α-secretase; APP processing; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the abnormal accumulation and aggregation of amyloid beta (Aβ) peptides within the brain. Generation of Aβ occur when the amyloid-beta precursor protein (APP) is proteolytically processed by β- and then γ-secretase in the amyloidogenic pathway. READ MORE

  3. 3. Gene therapy tools: oligonucleotides and peptides

    University dissertation from Stockholm : Department of Neurochemistry, Stockholm University

    Author : Jonas Eriksson; Ülo Langel; Jens Kurreck; [2016]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Gene therapy; oligonucleotide; peptide; RNA-cleaving deoxyribozyme; deoxyribozyme; DNAzyme; cell-penetrating peptide; CPP; enzyme; enzyme kinetics; kinetic assay; assay; telomerase; telomerase inhibitor; imetelstat; GRN163L; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Genetic mutations can cause a wide range of diseases, e.g. cancer. Gene therapy has the potential to alleviate or even cure these diseases. READ MORE

  4. 4. Cell-penetrating peptides as delivery vectors for oligonucleotides and proteins Studies on applications and toxicity

    University dissertation from Stockholm : Institutionen för neurokemi

    Author : Peter Järver; Ülo Langel; Gilles Divita; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE Chemistry Neurochemistry; MEDICIN Kemi Neurokemi; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Cell-penetrating peptides (CPPs) have for a little bit more than a decade been employed as delivery vectors for a wide range of cargoes, ranging from gold particles to entire plasmids. Although CPP are well studied and utilized in numerous publications, our knowledge about CPP mediated transport is still poor. READ MORE

  5. 5. The adaptor protein Fe65 and APP processing

    University dissertation from Stockholm : Department of Neurochemistry, Stockholm University

    Author : Niina Koistinen; Kerstin Iverfeldt; Susanne Frykman; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : The amyloid precursor protein (APP) protein has been in the limelight of research on Alzheimer´s disease (AD) pathogenesis because its proteolytic processing gives rise to the neurotoxic amyloid β (Aβ) peptide, the main constituent of amyloid plaques in the brains of AD patients. APP is sequentially processed by at least three different proteases termed α-, β-, and γ-secretases. READ MORE