Search for dissertations about: "Neurodegenerative disease"

Showing result 11 - 15 of 435 swedish dissertations containing the words Neurodegenerative disease.

2. 11. Microvascular brain raspberries: A clinicopathological study

   Author : Henric Ek-Olofsson; Lund Patologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cerebrovascular disease; cerebral small vessel disease; vascular dementia; neurodegenerative disease; frontotemporal lobar degeneration; hypertension;

   Abstract : .... READ MORE

4. 12. ­­­Visual assessment of perfusion and metabolism in neurodegenerative dementia

   Author : David Fällmar; Elna-Marie Larsson; Lena Kilander; Mark Lubberink; Ian Law; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dementia; Neurodegenerative; Brain imaging; Diagnostics; Neuroradiology; Neuroimaging; Demens; Neurodegenerativ; Hjärnavbildning; diagnostik; Neuroradiologi; Neuroimaging; Radiology; Radiologi;

   Abstract : A worldwide demographic shift is currently occurring, with rapidly increasing numbers of elderly individuals. Since the incidence of neurodegenerative disease generally increases with age, this entails an increase in dementia prevalence. READ MORE

5. 13. Markers of Prognosis in Neurodegenerative Dementia

   Author : Kajsa Stubendorff; Klinisk minnesforskning; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lewy body disease; Alzheimer s disease; dementia with Lewy bodies; prognosis; survival; longitudinal studies; biomarkers; cerebrospinal fluid; dysautonomic orthostatic hypotension; memantine;

   Abstract : Background: A prognostic marker should provide information about course and outcome of disease, e.g. predict time to a given endpoint or rate of progression due to disease in patients or subgroups of patients. Prognostic markers could be targeted to apply during the entire clinical course or just during distinct stages of the disease. READ MORE

6. 14. CRISPR/Cas9-based therapies and the role of astrocytes in Alzheimer’s disease and Parkinson’s disease

   Author : Evangelos Konstantinidis; Martin Ingelsson; Anna Erlandsson; Vilmantas Giedraitis; Magnus Essand; Harald Steiner; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Parkinson s disease; gene editing; CRISPR Cas9; amyloid-beta; astrocytes; neurons; iPSCs; electrophysiology;

   Abstract : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common neurodegenerative disorders. Whereas the AD brain features plaques of amyloid-beta (Aβ) and neurofibrillary tangles of tau, the PD brain is characterized by Lewy bodies and Lewy neurites containing α-synuclein (αSyn). READ MORE

7. 15. Lysosomal network proteins as biomarkers and therapeutic targets in neurodegenerative disease

   Author : Andrea Boman; Katarina Kågedal; Samuel Svensson; Alan Sabirsh; Per Svenningsson; Oskar Hansson; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cerebrospinal fluid CSF ; biomarkers; therapeutic targets; neurodegeneration; Alzheimer’s disease AD ; Parkinson’s disease PD ; Corticobasal degeneration CBD ; Progressive supraneuclear palsy PSP ; Lysosomes; Endosomes; Autophagy; LAMP-2; Lysozyme;

   Abstract : The pre-symptomatic stage of neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) occurs several decades before the clinical onset. Changes in the lysosomal network, i.e. the autophagosomal, endosomal and lysosomal vesicular system, are among the first alterations observed. READ MORE