Search for dissertations about: "Neuronal damage"
Showing result 1 - 5 of 140 swedish dissertations containing the words Neuronal damage.
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1. Neurofilaments as biomarkers of neuronal damage
Abstract : Different neurodegenerative diseases have overlapping symptomatology and pathology and have thus become a challenge to modern medicine to achieve a correct diagnosis. The aim of the thesis was to evaluate the use of neurofilaments as biomarkers of neuronal damage by testing their ability to discriminate between different neurodegenerative diseases as well as assessing whether higher neurofilments predict a poorer clinical outcome in ischemic stroke. READ MORE
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2. Sex Differences in Cardiac and Cerebral Damage after Hypovolemic Cardiac Arrest
Abstract : Resuscitation from haemorrhagic shock and the subsequent circulatory arrest remains a major clinical challenge in the care of trauma patients. Numerous experimental studies in sexually mature animals have shown a gender dimorphism in response to trauma and haemorrhagic shock. READ MORE
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3. Mechanisms of Brain Damage Following Focal Cerebral Ischemia: Changes in Ion Homeostasis and the Importance of Free Radical Formation
Abstract : In this thesis mechanisms of neuronal damage were investigated in an experimental stroke model i.e focal ischemia. The influence of SD-induced calcium transients on neuronal damage were studied in animals with reduced energy supply. READ MORE
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4. Neuroprotection and neurogenesis after experimental stroke
Abstract : In this thesis, two potential endogenous mechanisms for neuronal survival and repair have been investigated in a rat model of stroke, middle cerebral artery occlusion (MCAO): signaling of the GDNF family of neurotrophic factors, and neurogenesis from endogenous progenitor cells. As determined by in situ hybridization for GDNF family ligand and receptor genes, MCAO caused widespread upregulation of both components of the functional GDNF receptor, c-Ret and GFRalpha1, indicating that GDNF may be a survival signal in stroke. READ MORE
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5. Neurochemical and cognitive aftermaths of surgery - studies on short- and long-term effects of surgery and anesthesia
Abstract : Background: Each year, around the world, more than 230 million patients have surgery. Improvements in healthcare have resulted in older and sicker patients undergoing surgical interventions. As a result, surgical safety has be-come a global public-health concern. READ MORE