Search for dissertations about: "Neuronal excitability"

Showing result 1 - 5 of 36 swedish dissertations containing the words Neuronal excitability.

2. 1. Conductance-based principles of neuronal firing and excitability

   Author : Hugo Zeberg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The brain is an electrical organ whose activity is determined by the flow of ions across cell membranes. As such, the conductances that control the ion flux is a key to our understanding of the nervous system. Neurons process information by their ability to rapidly depolarize and fire action potentials. READ MORE

4. 2. Role of potassium channels in regulating neuronal activity

   Author : Göran Klement; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Potassium channels; threshold dynamics; trafficking; hERG; SMOCs; excitability;

   Abstract : The firing behaviour of excitable cells is fundamental for the information processing in multicellular organisms, varying from single spikes to different forms of repetitive firing. Of the many regulators, voltage gated potassium channels play a major role. In this thesis some aspects of the potassium channel regulation of firing are explored. READ MORE

5. 3. Dendritic and axonal ion channels supporting neuronal integration : From pyramidal neurons to peripheral nociceptors

   Author : Marcus Petersson; Erik Fransén; Theodore Cummins; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; ion channels; computational modeling; simulations; dendrites; axons; TRP; hippocampus; C-fiber nociceptors; pain;

   Abstract : The nervous system, including the brain, is a complex network with billions of complex neurons. Ion channels mediate the electrical signals that neurons use to integrate input and produce appropriate output, and could thus be thought of as key instruments in the neuronal orchestra. READ MORE

6. 4. Activity-regulated retinoic acid signaling in olfactory sensory neurons

   Author : Hande Login; Staffan Bohm; Mattias Alenius; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mouse olfactory system; RA; neuronal activity; CNG; Cyp26B1; BACE1; Kirrel-2; molekylärbiologi; Molecular Biology;

   Abstract : The aim of the studies included in the thesis is to better understand the interplay between neuronal activity-dependent gene regulation and the bioactive vitamin A metabolite all-trans-retinoic acid (RA) during postnatal development, refinement and maintenance of precise neuronal connectivity using the olfactory sensory neuron (OSN) in the olfactory epithelium (OE) of genetically modified mice as a model. We show that:Inhibition of RA receptor (RAR)-mediated transcription in OSNs reduces expression of the olfactory cyclic nucleotide-gated (CNG) ion channel, which is required for odorant receptor (OR)-mediated stimulus transduction. READ MORE

7. 5. Spike-Based Bayesian-Hebbian Learning in Cortical and Subcortical Microcircuits

   Author : Philip Tully; Anders Lansner; Matthias Hennig; Gordon Pipa; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Bayes rule; synaptic plasticity and memory modeling; intrinsic excitability; naïve Bayes classifier; spiking neural networks; Hebbian learning; neuromorphic engineering; reinforcement learning; temporal sequence learning; attractor network; Computer Science; Datalogi;

   Abstract : Cortical and subcortical microcircuits are continuously modified throughout life. Despite ongoing changes these networks stubbornly maintain their functions, which persist although destabilizing synaptic and nonsynaptic mechanisms should ostensibly propel them towards runaway excitation or quiescence. READ MORE