Search for dissertations about: "Neurotoxic"
Showing result 16 - 20 of 123 swedish dissertations containing the word Neurotoxic.
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16. Developmental Neurotoxicity of Environmental Pollutants : Effects on neuronal protein markers after neonatal exposure
Abstract : This thesis focused on investigations of the developmental neurotoxic effects of bisphenol A (BPA) or perfluorohexane sulfonate (PFHxS), after a single neonatal exposure, during a critical period of the brain development in mice.BPA is a well-known industrial chemical used in the production of polymer products and PFHxS is used as an industrial additive as a surfactant. READ MORE
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17. Alzheimer Aβ peptides induce dysregulation of C/EBP and NF-кB in glial cells
Abstract : Inflammation is believed to contribute to neurodegeneration in Alzheimer’s disease (AD). AD in turn is believed to be a consequence of accumulated amyloid-β (Aβ) peptides, that subsequently form senile plaques, due to imbalance between production and clearance of Aβ. READ MORE
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18. In vitro models to study mechanisms of neural cell death induced by toxic agents
Abstract : Neurotoxicity arises when exposure to toxic agents, either naturally occurring or manmade substances, alters the normal activity and/or structure of the nervous system. This can lead to disruption of vital metabolic processes and eventually to cell death. Certain unique features of the nervous system make it particularly vunerable to toxicants, e. READ MORE
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19. Development of specific monoclonal antibodies against different forms of alpha-synuclein as diagnostic tools for synucleinopathies
Abstract : Synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies(DLB) and multiple system atrophy (MSA), are a group of neurodegenerative disorders characterized by the abnormal accumulation of insoluble alpha-synuclein (α-syn) aggregates in the brain. The detection of α syn pathology has relied vastly on the use of several antibodies, which were mostly generated against different forms of α-syn. READ MORE
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20. Assessment of environmental contaminants' neurotoxicity : in vitro and in vivo experimental studies
Abstract : Accumulating evidence over several decades shows that environmental contaminants may lead to neurodevelopmental alterations. An essential prerequisite to prevention is recognition of a chemical‟s ability to harm the developing nervous system. READ MORE