Search for dissertations about: "Neurotransmitter synthesis"

Showing result 1 - 5 of 21 swedish dissertations containing the words Neurotransmitter synthesis.

  2. 1. Imaging and Quantification of Brain Serotonergic Activity using PET

    Author : Pinelopi Lundquist; Margareta Hammarlund-Udenaes; Per Hartvig; Gunnar Blomquist; Paul Cumming; Uppsala universitet; []
    Keywords : Pharmacokinetics Pharmacotherapy; Brain serotonin; Neurotransmitter release; Neurotransmitter synthesis; Positron emission tomography; Tracer validation; Tracer modelling; Farmakokinetik Farmakoterapi;

    Abstract : This thesis investigates the potential of using positron emission tomography (PET) to study the biosynthesis and release of serotonin (5HT) at the brain serotonergic neuron. As PET requires probe compounds with specific attributes to enable imaging and quantification of biological processes, emphasis was placed on the evaluation of these attributes. READ MORE

  4. 2. Cyclic guanosine 3', 5'-monophosphate : studies on synthesis and efflux from hepatocytes, liver slices and cerebellar slices and on serotonin-mediated cGMP synthesis in human platelets

    Author : Marie-Louise Tjörnhammar; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The present study established the existence of a carrier mediated transport of 3'5' cGMP from rat liver slices, hepatocytes and cerebellar slices in which the cellular levels of 3'5' cGMP were elevated by application of appropriate stimuli and inhibitors of the 3'5' cyclic nucleotide phosphodiesterase. The carrier is specific for 3'5' cGMP as opposed to 3'5' cAMP. READ MORE

  5. 3. Synthesis and evaluation of new PET radioloigands for imaging central norepinephrine transporters

    Author : Magnus Schou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : PET; Radioligand; NET; Brain;

    Abstract : The noradrenergic (NE), serotonergic (5-HT) and dopaminergic (DA) neurotransmission systems all have specific proteins responsible for the regulation of synaptic concentrations of neurotransmitter in the central nervous system (CNS) and in the periphery. Several reports have shown that the expression of these proteins, the monoamine transporters, within the CNS, may be altered in patients with certain neurodegenerative or neuropsychiatric disorders. READ MORE

  6. 4. Synthesis, Pharmacological Characterization and QSAR Modelling of 4-Phenylpiperidines and 4-Phenylpiperazines Effects on the dopaminergic neurotransmission in vivo

    Author : Fredrik Pettersson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; dopamine; D2; monoamine oxidase; DOPAC; in vivo; QSAR; dopaminergic stabilizer;

    Abstract : The endogenous neurotransmitter dopamine (DA) is involved in several functions that are controlled from the central nervous system (CNS), for example behaviour, memory, cognition and reward. A disturbed dopaminergic neurotransmission may lead to many severe conditions, such as schizophrenia, attention deficit hyperactivity disorder (ADHD) or Parkinson's disease (PD). READ MORE

  7. 5. Communication breakdown - synaptic dysfunction in Huntington's disease

    Author : Ruben Smith; Neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurodegeneration; Neurology; neuropsychology; neurophysiology; Neurologi; cholinergic neuron; exocytosis; transmitter release; intracellular transport; insulin; Huntington s disease; synapse; neuropsykologi; neurofysiologi;

    Abstract : Huntington's disease (HD) is a neurodegenerative disease caused by a CAG-triplet expansion in the gene encoding the protein huntingtin. The disease typically starts in mid-life and progresses for 15-20 years. To date no effective treatment is available for curing the disease. HD primarily affects the striatum, cerebral cortex and hypothalamus. READ MORE