Search for dissertations about: "Neurovascular unit"

Found 5 swedish dissertations containing the words Neurovascular unit.

  1. 1. Translational Aspects of Blood-Brain Barrier Transport and Brain Distribution of Drugs in Health and Disease

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sofia Gustafsson; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Neurovascular unit; Pharmacokinetics; Neurodegenerative disease; Drug transport; Brain tissue binding; Positron emission tomography; Brain regions; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : A high unmet medical need in the area of CNS diseases coincides with high failure rates in CNS drug development. Efficient treatment of CNS disease is constrained by limited entrance of drugs into the brain owing to the blood-brain barrier (BBB), which separates brain from blood. READ MORE

  2. 2. Microvascular plasticity and neurovascular coupling in the pharmacotherapy of Parkinson's disease

    University dissertation from Basal Ganglia Pathophysiology Unit

    Author : Elisabet Ohlin; Lunds universitet.; Lund University.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; levodopa; dyskinesia; angiogenesis; cerebral blood flow; blood-brain barrier;

    Abstract : Popular Abstract in Swedish Parkinsons sjukdom är en av våra mest förekommande neurologiska sjukdomar som drabbar den åldrande befolkningen. I åldersgruppen 50-60 år drabbas ca 1 procent av sjukdomen, som karakteriseras av de motoriska symptomen stelhet, långsamma rörelser och skakningar. READ MORE

  3. 3. Studies on pericytes in health and disease

    University dissertation from Stockholm : Karolinska Institutet, Department of Medical Biochemistry and Biophysics

    Author : Maya Hestnes Nisancioglu; Karolinska Institutet.; Karolinska Institutet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Pericytes are the perivascular mural cells of microvessels. They are intimately associated with endothelial cells and communicate with them via direct physical contact or through paracrine signaling pathways. These interactions are important for blood vessel maturation, remodeling, and maintenance. READ MORE

  4. 4. tPA mediated activation of PDGF-C/PDGFRα signaling in the CNS

    University dissertation from Stockholm : Karolinska Institutet, Dept of Medical Biochemistry and Biophysics

    Author : Christina Stefanitsch; Karolinska Institutet.; Karolinska Institutet.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The platelet derived growth factors (PDGFs) and their tyrosine kinase receptors play an essential role during development, in adult tissue homeostasis and in several pathological events. PDGF-CC, a ligand for PDGFRα, is secreted as an inactive dimer. READ MORE

  5. 5. MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia

    University dissertation from Lund University, Faculty of Medicine

    Author : Aida Maddahi; Lunds universitet.; Lund University.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitogen activated protein kinase; iNOS; Matrix metalloproteinases; IL-1ß; IL-6; TNF-α; Inflammation; Subarachnoid hemorrhage; Middle cerebral artery occlusion;

    Abstract : INTRODUCTION Stroke is a serious neurological disease which may lead to death and severe disability [1, 2]. There are two major types of stroke: ischemic and hemorrhagic stroke. READ MORE