Search for dissertations about: "Nevirapine"

Showing result 6 - 10 of 16 swedish dissertations containing the word Nevirapine.

  2. 6. HIV-1 genotype and vertical transmission in northern Vietnam

    Author : Thi Thanh Ha Tran; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : After 18 years from the beginning of the HIV-1/AIDS epidemic in Vietnam, the number of HIV-1 infected individuals is still increasing. Investigations conducted at two distinct time points in two separate groups of HIV-1 infected intravenous drug users (IDUs) and pregnant women in Northern Vietnam indicated that the HIV-1 CRF01_AE genotype is dominating in Northern Vietnam. READ MORE

  4. 7. Influencing HIV treatment success in India : do mobile phones really work?

    Author : Anita Shet; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV;

    Abstract : Background: Sustaining treatment adherence and long-term virological suppression is a global health challenge in HIV management. Mobile phone-based interventions are increasingly harnessed to enhance medication adherence in HIV infection, although supporting evidence for implementation is limited by lack of robust efficacy trials in settings such as India. READ MORE

  5. 8. Studies of drug resistance in minor HIV quasispecies

    Author : Halime Ekici; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The main objective was to study drug resistance mutations (DRM) in the HIV-1 reverse transcriptase (RT) gene of minor HIV-1 quasispecies, not detectable with standard techniques. Sensitive allele-specific PCR (AS- PCR) and next-generation sequencing (NGS) were developed to study resistance to drugs of relevance in low- and middle-income countries (LMIC); the nucleoside analogue RT inhibitor (NRTI) lamivudine (3TC) and the non-nucleoside RT inhibitors (NNRTIs) efavirenz (EFV) and nevirapine (NVP). READ MORE

  6. 9. Reverse transcriptase assay for analysis of resistance to anti-HIV drugs and their mechanism of action

    Author : Xingwu Shao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1; RT; antiviral drugs; NRTls; NNRTls; drug resistance; viral load;

    Abstract : Reverse transcriptase (RT) is a viral enzyme and one of the main targets for drugs against human immunodeficiency virus (HIV). This work presents a set of sensitive non-radioactive RT assays were developed: standard RT inhibition assay (IC assay); RT binding inhibition assay; RTprotein detection assay and template-primer destruction assay or chain termination assay (CT assay). READ MORE

  7. 10. Assays for monitoring HIV therapy in low-middle income countries

    Author : Eva Agneskog; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The purpose of this thesis was to develop and/or evaluate assays for HIV viral load (VL) monitoring and HIV drug resistance testing of potential importance for research studies and clinical care in low- and middle income countries (LMICs). This was achieved using reverse transcriptase based (RT) assays and blood samples from Vietnamese and Swedish HIV-1 infected patients. READ MORE