Search for dissertations about: "Nicholas Carl Kristoffer Valerie"

Found 1 swedish dissertation containing the words Nicholas Carl Kristoffer Valerie.

2. 1. Roles of NUDT5 and NUDT15 beyond oxidized nucleotide sanitation and their potential as therapeutic targets

   Author : Nicholas Carl Kristoffer Valerie; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The nucleotide precursor pool is readily susceptible to numerous sources of modification and damage, including alkylation, deamination and oxidation/nitrosylation, among others; most of which have deleterious effects on nucleic acid integrity and cellular fitness. In addition to DNA repair mechanisms, these metabolic byproducts are kept in check by so-called sanitation or “housekeeping” enzymes, chief among them the NUDIX hydrolase superfamily. READ MORE